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2008 Compendium of Evidence-Based HIV Prevention Interventions

The evidence-based interventions, listed in this 2008 Compendium, have been identified by PRS through a series of efficacy reviews. These interventions represent the strongest HIV behavioral interventions in the literature to date that have been rigorously evaluated and have demonstrated efficacy in reducing HIV or STD incidence or HIV-related risk behaviors or promoting safer behaviors.

The ongoing PRS efficacy review process has identified
57 evidence-based HIV behavioral interventions
(as of May 2008).

On December 19, 2008, eight new interventions were added. They include:

Best-Evidence Interventions:

Promising-Evidence Interventions:

These evidence-based interventions are catalogued as either best-evidence or promising-evidence. A complete listing of each catalogue is available below.

Best-Evidence Interventions
Promising-Evidence Interventions

The current listings of best-evidence and promising-evidence interventions include individual- and group-level behavioral interventions for high-risk populations whose evaluation study was published from 1988 through May 2008. PRS is continuously conducting the efficacy review to identify new evidence-based behavioral interventions and is currently reviewing community-level interventions. This website will be updated annually to provide timely information to the prevention field.

Other Interventions from the Original Compendium
Many interventions were identified through two earlier PRS efficacy reviews of the scientific literature between 1988 and 2000 (CDC, 1999[1]; Kay, 2003[17]). Interventions identified through these reviews had to satisfy the previous Compendium criteria. These criteria have since been strengthened in 2004 to reflect the progress in the field of HIV behavioral prevention research. A complete listing of the interventions identified in the original review can be found in the Compendium of HIV Prevention Interventions with Evidence of Effectiveness.


Last Modified: December 19, 2008
Last Reviewed: December 19, 2008
Content Source:
Divisions of HIV/AIDS Prevention
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
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