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Mycobacteriology Laboratory BranchReturn to Mycobacteriology Laboratory Main Page Drug susceptibility testingDrug susceptibility testing is a difficult procedure to standardize, and proficiency in performing these tests requires an understanding of many elements, including the
The MLB uses an indirect proportion method for testing M. tuberculosis and other slow-growing mycobacteria to 11 drugs at 35°C on Middlebrook 7H10 agar. The test requires 1 month to complete. Growth on the control medium is compared to the growth on the drug-containing medium to determine susceptibility or resistance. When performed properly, this method allows a quantitation of the proportion of mutants resistant to a drug and can detect the 1% proportion of drug- resistant mutants above which therapeutic failure is likely. Slow growing mycobacteria are tested with the following drugs:
Last Reviewed: 05/18/2008 |
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Centers for Disease Control & Prevention |