Under Phase I of ToxCastTM, the chemicals will be examined via high throughput screening (HTS) bioassays. Phase I will be used to create chemical signatures of compounds which will then be compared to known toxicity data in this proof-of-concept phase. It is expected that patterns will emerge that are predictive of compounds that could cause harm to people and the environment. Results of Phase I are expected in 2008, and will be posted on the ToxCastTM Web site. Phase II will involve a larger, more diverse set of chemicals to test the predictability of patterns identified in Phase I. In Phase III, ToxCastTM will expand the list to thousands of environmental chemicals, delivering an affordable, science-based system for decision-makers.
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Executive Order 13423
