For May 13, 1998

Dr. Bryan Brewer received his undergraduate degree from Johns Hopkins University and his medical degree from Stanford University School of Medicine. After completing an internship and residency in internal medicine at the Massachusetts General Hospital, he joined the National Heart, Lung, and Blood Institute as a clinical associate. Dr. Brewer was promoted to head of the Peptide Chemistry Section in the Molecular Disease Branch, and then to chief of that Branch, a position he has held since 1976.

Dr. Brewer's areas of research include the human plasma apolipoproteins, the genetic dyslipoproteinemias, lipoprotein metabolism, and atherosclerosis. He has pioneered the use of transgenic mice and rabbits and recombinant adenovirus vectors to identify genes that modulate lipoprotein metabolism and the development of atherosclerosis.

Today, Dr. Brewer will discuss "LCAT: A New Gene Target for the Treatment of High Cholesterol."

Dr. Paul Plotz and Dr. John Michael Vlach will discuss "Molecular Roots: The African Origin ­ Genetic and Historical ­ of a Muscle Disease in African Americans."

Dr. Plotz earned both a bachelor's degree in physics and a medical degree from Harvard. After an internship and assistant residency in internal medicine at the Beth Israel Hospital in Boston, Dr. Plotz came to NIH in 1965 as a clinical associate in the Arthritis Institute. He has been chief of the NIAMS Connective Tissue Diseases Section since 1984, and since 1994 has also been chief of the Arthritis and Rheumatism Branch. Dr. Plotz has done research on affinity labeling in the search for antigen recognition sites, the removal of substances from blood by affinity chromatography, autoimmune diseases of the liver, the side effects of salicylates in the treatment of rheumatic diseases, and immune system abnormalities in the idiopathic inflammatory myopathies.

Dr. Vlach is Professor of American Civilization and Anthropology and Director of the Folklife Program for George Washington University's American Studies Program. While at George Washington, he established the Ph.D. and M.A. concentrations in folklife. In addition to prior academic appointments at the University of Maryland and the University of Texas, Dr. Vlach has held visiting appointments at Boston University, the University of Hawaii, and Armstrong State College.

Dr. Vlach earned a bachelor's degree in American History and Literature at the University of California at Davis and, after attending the University of Ghana, earned a master's and Ph.D. in Folklore at Indiana University. Author of eight books and numerous book chapters and journal articles, Dr. Vlach has chaired the National Endowment for the Arts folk arts panel and is a member of the Smithsonian's national faculty. He has curated museum exhibits at institutions across the country, including the Boston Museum of Fine Arts, the Cleveland Museum of Art, the Institute of Texas Cultures, and the Library of Congress.



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