The Registry of Toxic Effects of Chemical Substances

Hydrazine

RTECS #: MU7175000

CAS #: 302-01-2

UPDATE: May 2008 MW: 32.06 MF: H4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Hydrazine (ACGIH:OSHA)
  2. Hydrazine fume
  3. Hydrazyna (Polish)
  4. Levoxine
  1. Nitrogen hydride
  2. Oxytreat 35
  3. RCRA waste number U133


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 10 µmol/L MUREAV 89,95,1981
DNA damage oral
hamster 		15 mg/kg PAACA3 24,59,1983
DNA damage human lung 0.5 mmol/L/20 hour MUREAV 605,94,2006
DNA damage mammal (species unspecified) lymphocyte 95 pph BBACAQ 174,591,1969
DNA damage intraperitoneal
mouse 		100 mg/kg MUREAV 415,1,1998
DNA damage oral
mouse 		100 mg/kg MUREAV 415,1,1998
DNA damage rat liver 3 mmol/L MUREAV 113,357,1983
DNA damage rat lung 0.5 mmol/L/20 hour MUREAV 605,94,2006
DNA damage oral
rat 		30 mg/kg MUREAV 605,94,2006
DNA inhibition human HeLa cell 50 µmol/L CNREA8 44,59,1984
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
DNA inhibition oral
rat 		60 mg/kg CRNGDP 4,953,1983
unscheduled DNA synthesis hamster ovary 250 µg/L NTIS** AD-A075-605
unscheduled DNA synthesis hamster lung 250 µg/L NTIS** AD-A075-605
unscheduled DNA synthesis oral
rat 		60 mg/kg CRNGDP 4,953,1983
unscheduled DNA synthesis rat lung 250 µg/L NTIS** AD-A075-605
mutation in microorganisms Escherichia coli 4,300 µmol/L (+enzymatic activation step) TOLED5 31,131,1986
mutation in microorganisms Haemophilus influenzae 2 mmol/L (-enzymatic activation step) MUREAV 30,9,1975
mutation in microorganisms other microorganisms 70 µg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 120 µg/plate (-enzymatic activation step) BIZNAT 97,137,1978
mutation in microorganisms Saccharomyes cerevisiae 200 mmol/L (-enzymatic activation step) MUREAV 93,339,1982
mutation in mammalian somatic cells mouse lymphocyte 1 mmol/L MUREAV 89,321,1981
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
morphological transform human liver 80 µg/L BJCAAI 37,873,1978
morphological transform human other cell types 35 mg/L ITCSAF 17,719,1981
other mutation test systems Bacillus subtilis 10 mmol/L MUREAV 5,343,1968
other mutation test systems Escherichia coli 80 pmol/tube MUREAV 147,79,1985
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		10 mmol/L MUREAV 16,363,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 1 ppm/6 hour (1 year male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 5,1050,1985
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/2 hour (7-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) GISAAA 39(10),23,1974
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/24 hour (1-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 39(10),23,1974
inhalation
rat 		lowest published toxic concentration: 1 mg/m3 (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVN5* -,20,1989
intraperitoneal
mouse 		lowest published toxic dose: 48 mg/kg (6-9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** AD-A084-023
intraperitoneal
mouse 		lowest published toxic dose: 80 mg/kg (6-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** AD-A084-023
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) APTOD9 19,A21,1980
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) APTOD9 19,A21,1980
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg (7-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** AD-A119-706
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** AD-A119-706
subcutaneous
rat 		lowest published toxic dose: 80 mg/kg (11-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		AEHLAU 21,615,1970
skin
rat 		lowest published toxic dose: 50 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** AD-A119-706


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 1 ppm/6 hour/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors 		FAATDF 5,1050,1985
inhalation
hamster 		toxic concentration (other than lowest) : 5 ppm/6 hour/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		PAACA3 21,74,1980
inhalation
mouse 		lowest published toxic concentration: 1 ppm/6 hour/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		PAACA3 21,74,1980
inhalation
rat 		lowest published toxic concentration: 5 ppm/6 hour/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		FAATDF 5,1050,1985
inhalation
rat 		toxic concentration (other than lowest) : 5 ppm/6 hour/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		PAACA3 21,74,1980
inhalation
rat 		toxic concentration (other than lowest) : 1 ppm/6 hour/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		PAACA3 21,74,1980
intraperitoneal
mouse 		lowest published toxic dose: 400 mg/kg/5 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Blood: Leukemia 		UICMAI 7,180,1967
oral
mouse 		lowest published toxic dose: 1,951 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		IJCNAW 9,109,1972
oral
rat 		lowest published toxic dose: 900 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		EXPADD 33,133,1988


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 252 ppm/4 hour Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 12,609,1955
inhalation
mouse 		lethal concentration (50 percent kill): 1,000 mg/m3/2 hour N/R VCVN5* -,20,1993
inhalation
mouse 		lethal concentration (50 percent kill): 320 mg/m3/4 hour N/R VCVN5* -,20,1993
inhalation
mouse 		lethal concentration (50 percent kill): 330 gm/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Liver: Other changes 		TPKVAL 4,65,1962
inhalation
mouse 		lowest published lethal concentration: 1.5 gm/m3/2 hour Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Blood: Changes in spleen 		TPKVAL 4,65,1962
inhalation
mouse 		lowest published toxic concentration: 0.65 gm/m3/2 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Fatty liver degeneration 		TPKVAL 4,65,1962
inhalation
mouse 		lowest published toxic concentration: 0.2 gm/m3 N/R TPKVAL 4,65,1962
inhalation
rat 		lethal concentration (50 percent kill): 570 ppm/4 hour Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 12,609,1955
inhalation
rat 		lethal concentration (50 percent kill): 130 mg/m3/2 hour N/R VCVN5* -,20,1993
inhalation
rat 		lowest published toxic concentration: 20,000 mg/m3/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Behavioral: Excitement

Behavioral: Tetany 		VCVN5* -,20,1993
inhalation
rat 		lowest published toxic concentration: 23 ppm/10 minute Olfaction: Deviated nasal septum TOXID9 44,303,2005
inhalation
rat 		lowest published toxic concentration: 16 ppm/30 minute Olfaction: Deviated nasal septum TOXID9 44,303,2005
inhalation
rat 		lowest published toxic concentration: 13 ppm/1 hour Olfaction: Deviated nasal septum TOXID9 44,303,2005
inhalation
rat 		lowest published toxic concentration: 3.1 ppm/4 hour Olfaction: Deviated nasal septum TOXID9 44,303,2005
inhalation
rat 		lowest published toxic concentration: 1.6 ppm/8 hour Olfaction: Deviated nasal septum TOXID9 44,303,2005
inhalation
rat 		lowest published lethal concentration: 64 ppm/10 minute N/R TOXID9 44,303,2005
inhalation
rat 		lowest published lethal concentration: 45 ppm/30 minute N/R TOXID9 44,303,2005
inhalation
rat 		lowest published lethal concentration: 35 ppm/1 hour N/R TOXID9 44,303,2005
inhalation
rat 		lowest published lethal concentration: 8.9 ppm/4 hour N/R TOXID9 44,303,2005
inhalation
rat 		lowest published lethal concentration: 4.4 ppm/8 hour N/R TOXID9 44,303,2005
inhalation
rat 		lethal concentration (50 percent kill): 750 gm/m3/4 hour Brain and Coverings: Increased intracranial pressure

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance 		TPKVAL 4,65,1962
inhalation
rat 		lowest published lethal concentration: 1.5 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 4,65,1962
inhalation
rat 		lowest published toxic concentration: 0.65 gm/m3/2 hour Behavioral: Alteration of classical conditioning TPKVAL 4,65,1962
inhalation
rat 		lowest published lethal concentration: 0.2 gm/m3 Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage 		TPKVAL 4,65,1962
intramuscular
dog 		lethal dose (50 percent kill): 16,500 µg/kg N/R GISAAA 16(6),53,1972
intramuscular
rat 		lethal dose (50 percent kill): 53,500 µg/kg N/R GISAAA 16(6),53,1972
intramuscular
rabbit 		lethal dose (50 percent kill): 38,500 µg/kg N/R GISAAA 16(6),53,1972
intraperitoneal
cat 		lowest published toxic dose: 20 mg/kg Behavioral: Tetany VCVN5* -,20,1993
intraperitoneal
mouse 		lethal dose (50 percent kill): 62 mg/kg N/R MEPAAX 24,71,1973
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 72,94,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 59 mg/kg N/R MEPAAX 24,71,1973
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Behavioral: Alteration of classical conditioning VCVN5* -,20,1993
intravenous
dog 		lethal dose (50 percent kill): 25 mg/kg N/R MEPAAX 24,71,1973
intravenous
dog 		lowest published lethal dose: 25 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage 		TPKVAL 4,65,1962
intravenous
mouse 		lethal dose (50 percent kill): 57 mg/kg N/R MEPAAX 24,71,1973
intravenous
mouse 		lowest published lethal dose: 55 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TPKVAL 4,65,1962
intravenous
rat 		lethal dose (50 percent kill): 55 mg/kg N/R MEPAAX 24,71,1973
intravenous
rat 		lowest published lethal dose: 55 mg/kg Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		TPKVAL 4,65,1962
intravenous
rabbit 		lethal dose (50 percent kill): 20 mg/kg N/R AMIHBC 9,199,1954
oral
mouse 		lethal dose (50 percent kill): 59 mg/kg N/R MEPAAX 24,71,1973
oral
mouse 		lethal dose (50 percent kill): 59 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVN5* -,20,1993
oral
mouse 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 72,94,2003
oral
mouse 		lowest published toxic dose: 250 mg/kg Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 204,135,2005
oral
mouse 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 78,353,2004
oral
mouse 		lowest published toxic dose: 300 mg/kg Liver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 78,353,2004
oral
mouse 		lethal dose (50 percent kill): 80 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		TPKVAL 4,65,1962
oral
rat 		lethal dose (50 percent kill): 60 mg/kg N/R MEPAAX 24,71,1973
oral
rat 		lethal dose (50 percent kill): 60 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVN5* -,20,1993
oral
rat 		lowest published toxic dose: 75 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain CRTOEC 14,975,2001
oral
rat 		lowest published toxic dose: 90 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Blood: Changes in other cell count (unspecified) 		CRTOEC 14,975,2001
oral
rat 		lowest published toxic dose: 120 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Other changes 		CRTOEC 14,975,2001
oral
rat 		lowest published toxic dose: 90 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 204,135,2005
subcutaneous
mouse 		lowest published toxic dose: 30 mg/kg Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Increase in cellular immune response 		TXCYAC 172,35,2002
skin
dog 		lowest published lethal dose: 96 mg/kg N/R TXAPA9 21,186,1972
skin
dog 		lowest published toxic dose: 3 mg/kg Behavioral: Tetany

Behavioral: Alteration of classical conditioning 		VCVN5* -,20,1993
skin
dog 		lowest published toxic dose: 100 mg/m3 Behavioral: Tetany

Behavioral: Alteration of classical conditioning 		VCVN5* -,20,1993
skin
guinea pig 		lethal dose (50 percent kill): 190 mg/kg Behavioral: Convulsions or effect on seizure threshold XAWPA2 CWL 2-10,1958
skin
mouse 		lowest published toxic dose: 100 pph/1 hour Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Liver: Fatty liver degeneration 		TPKVAL 4,65,1962
skin
rabbit 		lethal dose (50 percent kill): 91 mg/kg N/R AMIHBC 9,199,1954
skin
rabbit 		lowest published toxic dose: 50 pph/1 hour Skin: After topical application: Primary irritation TPKVAL 4,65,1962
unreported route
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R BJCAAI 6,160,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 14 ppm/6 hour/26 week- intermittent Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 10,476,1954
inhalation
guinea pig 		lowest published toxic concentration: 14 ppm/6 hour/14 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 10,476,1954
inhalation
guinea pig 		lowest published toxic concentration: 5 mg/m3/24 hour/59 day- continuous Lung, Thorax, or Respiration: Other changes VCVN5* -,20,1989
inhalation
hamster 		lowest published toxic concentration: 1 ppm/6 hour/1 year- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes 		NTIS** AD-A086-341
inhalation
monkey 		lowest published toxic concentration: 1 ppm/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** AD-A086-341
inhalation
mouse 		lowest published toxic concentration: 1 ppm/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** AD-A086-341
inhalation
mouse 		lowest published toxic concentration: 14 ppm/6 hour/5 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AMIHBC 10,476,1954
inhalation
mouse 		lowest published toxic concentration: 130 mg/m3/1 hour/17 week- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count 		VCVN5* -,20,1989
inhalation
mouse 		lowest published toxic concentration: 0.3 gm/m3/30 day- intermittent Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 4,65,1962
inhalation
rat 		lowest published toxic concentration: 1 ppm/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** AD-A086-341
inhalation
rat 		lowest published toxic concentration: 5 ppm/6 hour/26 week- intermittent Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 10,476,1954
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/30 day- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in bone marrow not included in above 		GISAAA 40(3),29,1975
inhalation
rat 		lowest published toxic concentration: 0.3 gm/m3/91 day- intermittent Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TPKVAL 4,65,1962
inhalation
rat 		lowest published toxic concentration: 0.5 gm/m3/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 4,65,1962
inhalation
rat 		lowest published toxic concentration: 0.5 gm/m3/213 day- intermittent Behavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage 		TPKVAL 4,65,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,127,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,991,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,223,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,991,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,991,1999
TOXICOLOGY REVIEW
AMIHBC 9,199,1954
TOXICOLOGY REVIEW
ATXKA8 28,135,1971
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
ENTOX* -,536,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (1.3 mg/m3) (skin) DTLVS* 3,127,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (1.3 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (1.3 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (1.3 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (1.3 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.1 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA TRK 0.13 mg/m3 (0.1 mL/m3), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.013 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm, short term exposure limit 0.3 ppm, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.13 mg/m3), skin, 2B carcinogen, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.13 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.1 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.01 ppm (0.013 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.13 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.13 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.02 ppm;
short term exposure limit 0.1 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-air Carcinogen ceiling concentration 0.03 ppm/120 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 38110;
Number of Industries 37;
Total Number of Facilities 2,134;
Number of Occupations 27;
Total Number of Employees Exposed 11,185
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 38110;
Number of Industries 44;
Total Number of Facilities 2,515;
Number of Occupations 46;
Total Number of Employees Exposed 60,490;
Total Number of Female Employees Exposed 2,841


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101025/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as rocket fuel and as intermediate in the preparation of other compounds
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8619;8EHQ-0593-9056
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrazine, 3503
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #20
OSHA ANALYTICAL METHOD #108


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CODEN
REFERENCE
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XAWPA2 U.S. Army Chemical Warfare Laboratories. (Army Chemical Center, MD)

Used as rocket fuel and as intermediate in the preparation of other compounds

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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