Licensing & Royalties >> Licensing Opportunities >> Abstract Details   Cloned Genomes Of Infectious Hepatitis C Virus And Uses Thereof Description of Invention: The current invention provides nucleic acid sequences comprising the genomes of infectious hepatitis C viruses (HCV) of genotype 1a and 1b. It covers the use of these sequences, and polypeptides encoded by all or part of the sequences, in the development of vaccines and diagnostic assays for HCV and the development of screening assays for the identification of antiviral agents for HCV. Additional information can be found in: Yanagi et al., "Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee," Proc. Natl. Acad. Sci. USA (1997 August) 94(16):8738-8743; and Yanagi et al., "Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo," Virology (25 April 1998) 244(1):161-172. Inventors: Masayuki Yanagi (NIAID) Jens Bukh (NIAID) Suzanne U. Emerson (NIAID) Robert H. Purcell (NIAID) Patent Status: DHHS Reference No. E-050-1998/0 -- U.S. Patent No. 6,153,421 issued 28 Nov 2000 U.S. Patent No. 7,201,911 issued 10 Apr 2007 U.S. Patent Application No. 11/784,809 filed 09 Apr 2007 Foreign rights are available. Related Technologies: DHHS Reference No. E-100-1999/0 -- "Cloned Genome of Infectious Hepatitis C Virus of Genotype 2a and Uses Thereof" DHHS Reference No. E-102-1999/0 -- "HCV/BVDV Chimeric Genomes and Uses Thereof" DHHS Reference No. E-173-1999/0 -- "Infectious cDNA Clone of GB Virus B and Uses Thereof" Portfolios: Infectious Diseases Infectious Diseases -Therapeutics For Additional Information Please Contact: RC Tang JD, LLM NIH Office of Technology Transfer 6011 Executive Blvd, Suite 325 Rockville, MD 20852-3804 Phone: 301/435-5031 Email: tangrc@mail.nih.gov Fax: 301/402-0220 Web Ref: 347 Last Updated On: 6/05