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Blood Disorders
Blood Disorders > thrombophilia / Clotting Disorders
Thrombophilia / Clotting Disorders

Photo of familyHereditary defects in one or more of the clotting factors can cause the formation of potentially dangerous blood clots (thrombosis). Approximately 5-8% of the U.S. population has one of these clotting disorders collectively called thrombophilia, a propensity for blood clotting in which a genetic defect can be identified that often results in thrombosis.

More than 60,000 Americans die each year from venous thromboembolism; in addition, nearly half of patients with deep vein clots experience long-term health consequences that adversely affect their quality of life.

Prevention activities

CDC is helping to establish a network of thrombosis and hemostasis centers to conduct epidemiologic research on thrombosis and thrombophilia and promote the management, treatment, and prevention of complications experienced by people with clotting disorders.

CDC is conducting laboratory work to identify genetic risk factors that predispose persons to thrombophilia. Identifying these factors could help prevent complications that result from clotting.

For more information


Locate a hemostasis and thrombosis center


Summary of CDC April 2000 meeting on the factor V Leiden mutation (33 KB) Adobe Acrobat file format

Dowling NF. Beckman MG. Manco-Johnson M. Hassell K. Philipp CS. Michaels LA. Moll S. Heit JA. Penner J. Kulkarni R. Pipe S. Bockenstedt P. Andersen J. Crudder S. James AH. Zimmerman S. Ortel TL. The U.S. Thrombosis and Hemostasis Centers pilot sites program. Journal of Thrombosis & Thrombolysis. 23(1):1-7, 2007. [full text]

Dowling NF. Austin H. Dilley A. Whitsett C. Evatt BL. Hooper WC. The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study. Journal of Thrombosis & Haemostasis. 1(1):80-7, 2003. [full text]

Hooper WC, Evatt BL. The role of activated protein C resistance in the pathogenesis of venous thrombosis. Am J Med Sci 1998;216:120-128.
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International Society on Thrombosis and Haemostasis

National Alliance for Thrombosis and Thrombophilia

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Date: November 21, 2005
Content source: National Center on Birth Defects and Developmental Disabilities


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