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The Immunization Safety Office Scientific Agenda

In response to a 2005 Institute of Medicine (IOM) recommendation* and to guide the Immunization Safety Office's (ISO's) scientific direction, ISO is developing a five-year ISO Scientific Agenda to guide its vaccine safety science in three areas:

  • Research

  • Surveillance (monitoring)

  • Guidance for healthcare providers

How will the ISO Scientific Agenda be used?

The Immunization Safety Office will use the agenda to guide its research and monitoring activities for the next five years. The agenda will help ISO monitor the safety of vaccines used in the Unite States. and conduct research to help ensure that vaccines are as safe as possible.

How is the ISO Scientific Agenda being developed?

During 2007-2008, ISO gathered input at three planned meetings with federal, academic and vaccine manufacturer scientists to begin drafting the Scientific Agenda. To continue gathering input, the Department of Health and Human Services (HHS) is conducting an external review process. The HHS external advisors, operating under the oversight of the National Vaccine Advisory Committee (NVAC), are looking at the agenda in depth to provide advice on the most important research that the Immunization Safety Office should focus on within the next five years.

What are the next steps?

Talking to the public about health issues like vaccine safety is an important part of how the government guides its work. HHS is organizing meetings in three cities to hear input from members of the public about ISO's Scientific Agenda. Meeting dates and locations are:

  • December 13--Birmingham, Alabama (completed)

  • January 10--Ashland, Oregon

  • January 17--Indianapolis, Indiana

After the public meetings, a group of vaccine safety stakeholders will meet to provide additional input to NVAC to help in guiding their scientific review of the ISO agenda.

ISO is expected to receive input from this NVAC scientific review in 2009. The input will help ISO finalize its Scientific Agenda so that it can continue to meet its mission of helping to ensure that vaccines are as safe as possible.

How can I get involved?

You can stay up-to-date on the public participation activities by visiting the HHS web page at

For more information about registering for the public participation meetings, please go to the registration page at

Visit the ISO web page for important vaccine safety information at


Draft ISO Scientific Agenda background document in Microsoft® Word format (289KB) or PDF format (103KB).

Draft recommendations for the ISO Scientific Agenda in Microsoft® Word format (597KB) or PDF format (463KB).

Draft recommendations addendum in Microsoft® Word format (44KB) or PDF format (40KB).

Reports from 2007 Scientific Agenda Meetings

*Links to non-Federal organizations found at this site are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization Web pages found at these links.

Page last reviewed: September 24, 2008
Page last updated: December 30, 2008
Content source: Immunization Safety Office

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