European MistletoeKeywords: headache, cancer, viscum album
On this page
- What It Is Used For
- How It Is Used
- What the Science Says
- Side Effects and Cautions
- For More Information
This fact sheet provides basic information about the herbA plant or part of a plant used for its flavor, scent, or potential therapeutic properties. Includes flowers, leaves, bark, fruit, seeds, stems, and roots. European mistletoe—common names, uses, potential side effects, and resources for more information. European mistletoe is a semiparasitic plant that grows on several types of trees in temperate regions worldwide. Where the term "mistletoe" is used in this fact sheet, it refers to European mistletoe. (European mistletoe is different from American mistletoe, which is used as a holiday decoration.)
Common Names—European mistletoe, mistletoe
Latin Name—Viscum album L.
What It Is Used For
- Mistletoe has been used for centuries in traditional medicine to treat seizures, headaches, and other conditions.
- Mistletoe is used mainly in Europe as a treatment for cancer.
How It Is Used
- The leafy shoots and berries of mistletoe are used to make extracts that can be taken by mouth.
- In Europe, mistletoe extracts are prescription drugs that are given by injection. In the United States, mistletoe by injection is available only in clinical trials.
What the Science Says
- Laboratory studies have found that mistletoe kills cancer cells and stimulates the immune system.
- The use of mistletoe to treat cancer has been studied in Europe in more than 30 clinical trials. Although improvements in survival or quality of life have been reported, almost all of the trials had major weaknesses in their design that raise doubts about the findings. For example, many of the studies had a small number of participants or did not have a control group.
- NCCAM is sponsoring a clinical trial of mistletoe, given in combination with the drug gemcitabine, for cancer. The study will look at toxicity, safety, and immune system effects of mistletoe extract when combined with this chemotherapy drug.
Side Effects and Cautions
- Raw, unprocessed mistletoe is poisonous. Eating raw, unprocessed European mistletoe or American mistletoe can cause vomiting, seizures, a slowing of the heart rate, and even death. American mistletoe is unsafe for medicinal use.
- In countries where commercial mistletoe is available by injection, such as Germany, those extracts are considered to be generally safe when used according to product directions and under the supervision of a health care provider.
- Injected mistletoe extract may cause itching or redness in the area of the injection. Less commonly, side effects may include more extensive skin reactions, low-grade fevers, or flu-like symptoms. There have been very rare reports of more serious allergic reactions, such as difficulty breathing.
- Because mistletoe has not yet been proven to be a safe and effective cancer treatment, it should not be used outside of clinical trials.
- Tell your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
- National Cancer Institute. Mistletoe Extracts (PDQ). National Cancer Institute Web site. Accessed on July 3, 2007.
- National Center for Complementary and Alternative Medicine. Frequently Asked Questions About the Mistletoe-Gemcitabine Study. National Center for Complementary and Alternative Medicine Web site. Accessed on July 3, 2007.
- European mistletoe. Natural Medicines Comprehensive Database Web site. Accessed on June 29, 2007.
- American mistletoe. Natural Medicines Comprehensive Database Web site. Accessed on July 3, 2007.
- Mistletoe (Viscum album L.) Natural Standard Database Web site. Accessed on June 28, 2007.
For More Information
- What's in the Bottle? An Introduction to Dietary Supplements
- Herbal Supplements: Consider Safety, Too
The NCCAM Clearinghouse provides information on CAM and NCCAM, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.
Toll-free in the U.S.: 1-888-644-6226
TTY (for deaf and hard-of-hearing callers): 1-866-464-3615
Web site: nccam.nih.gov
CAM on PubMed
Web site: nccam.nih.gov/camonpubmed/
NIH Office of Dietary Supplements
Web site: ods.od.nih.gov
This publication is not copyrighted and is in the public domain. Duplication is encouraged.
NCCAM has provided this material for your information. It is not intended to substitute for the medical expertise and advice of your primary health care provider. We encourage you to discuss any decisions about treatment or care with your health care provider. The mention of any product, service, or therapy is not an endorsement by NCCAM.
NCCAM Publication No. D270
Created July 2005
Updated April 2008
Note: The PDF file requires a viewer such as Adobe Reader, which you can download free of charge from the Adobe Web site.