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Abstract
Grant Number: 1F31AT002835-01A1 Project Title: Effects of CAMs on EGFR-Targeted Therapy
PI Information: Name Title RINELLA, ERICA S. erinella@med.unc.edu Abstract: DESCRIPTION (provided by applicant): Complementary and alternative medicines (CAM) are becoming increasingly popular among cancer patients as a means to counteract the toxic effects of chemotherapeutics. Non-conventional therapies like CAMs might provide additive or synergistic effects, but may also counteract the effectiveness of established medical treatments. In the proposed studies, we will use three mouse models for colorectal cancer (CRC), the ApcMin/+ model, the azoxymethane (AOM) model and the MC38 syngeneic transfer model, to examine the interaction between CAMs and EGFR inhibition, an emerging molecule-targeted treatment for colorectal and other cancers. The proposed studies will test the effect of commonly used biological-based CAMs, green tea and Vitamin D, on the effectiveness of EGFR-targeted treatment and evaluate whether interactions occur between the therapies. The CAMs were chosen based on scientific evidence for their potential roles in inhibiting colorectal carcinogenesis and their frequency of use. We hypothesize that combinations of currently acceptable medical treatments and CAMs will have unpredictable interactions that may significantly impact, either positively or negatively, the efficacy of standard treatments.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
alternative medicine, epidermal growth factor, growth factor receptor, neoplasm /cancer chemotherapy
colorectal neoplasm, combination therapy, human therapy evaluation, tea, therapy adverse effect, vitamin D
high performance liquid chromatography, immunocytochemistry, laboratory mouse, predoctoral investigator
Institution: UNIVERSITY OF NORTH CAROLINA CHAPEL HILL Office of Sponsored Research CHAPEL HILL, NC 27599 Fiscal Year: 2005 Department: GENETICS Project Start: 26-SEP-2005 Project End: 25-SEP-2008 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1