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Abstract
Grant Number: 5F32AT001569-03 Project Title: Anti-inflammatory effects of Bromelain
PI Information: Name Title SECOR, ERIC R. esecor@uchc.edu CLINICAL INSTRUCTOR Abstract: DESCRIPTION (provided by applicant): Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
antiinflammatory agent, biotherapeutic agent, cysteine endopeptidase, immunoregulation, nonhuman therapy evaluation, plant extract, respiratory disorder, respiratory disorder chemotherapy
alternative medicine, cytokine, disease /disorder model, dosage, immunoglobulin E, immunoglobulin G, lung lavage, lymphocyte, ovalbumin, respiratory function, spleen
enzyme linked immunosorbent assay, flow cytometry, histology, laboratory mouse, nutrition related tag, postdoctoral investigator
Institution: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT Office of Research & Sponsored Programs FARMINGTON, CT 06030 Fiscal Year: 2006 Department: MEDICINE Project Start: 23-FEB-2004 Project End: 22-FEB-2007 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1