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Abstract
Grant Number: 5R01AT002086-03 Project Title: Cranberry Juice and Urinary Tract Infections
PI Information: Name Title BARBOSA-CESNIK, CIBELE T. cibele@umich.edu Abstract: DESCRIPTION (provided by applicant): Urinary tract infection (UTI) is one of the most commonly acquired bacterial infections in ambulatory and hospitalized populations and E.coli is the most common urinary pathogen, accounting for 90% of UTIs acquired in the community. Antimicrobial treatment and prophylaxis has resulted in increasing resistance to antimicrobials among uropathogenic bacteria both in the United States and worldwide. Several observational studies and a few randomized trials suggest that cranberry juice reduces the incidence of UTI. Reduced incidence of UTI could decrease antibiotic use and ultimately minimize prevalence of antibiotic resistance. Our overall goal is to determine the effect of cranberry on reducing the rate of recurrent UTI and duration of symptoms over antibiotics alone. We propose a randomized clinical trial of 600 college women presenting to the University Health Service with acute urinary tract infection. The study will have 3 arms and patients will be randomly assigned to taking 8 ounces of juice twice a day containing either 27% cranberry juice, 13.5% cranberry juice, or placebo juice. In addition, we will determine whether regularly taking cranberry juice changes the 3 and 6 month prevalence of bladder, rectal, vaginal and periurethral colonization with E coli containing known uropathogenic virulence factors relative to placebo controls. The results of this study will increase our understanding of the cranberry juice effect on reducing the symptoms of acute UTI, and on preventing recurring UTIs. We will be able to understand the dose-response effects on the outcomes of interest, including on side effects and compliance. We will also be able to evaluate if the bacterial population in the vagina, periurethra and stool is different after regularly drinking cranberry juice compared to placebo.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
Escherichia coli infection, diet therapy, fruit, urinary tract infection
dietary supplement, disease /disorder prevention /control, drug resistance, longitudinal human study, rectum /anus, urethra, urinary bladder, vagina, women's health
alternative medicine, clinical research, female, human subject, nutrition related tag, patient oriented research
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR 3003 SOUTH STATE STREET, Room 1040 ANN ARBOR, MI 481091274 Fiscal Year: 2006 Department: EPIDEMIOLOGY Project Start: 15-JAN-2004 Project End: 31-DEC-2007 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1