The Defense Threat Reduction Agency (DTRA) recently celebrated its tenth anniversary. DTRA works closely with intra-agency, inter-agency, and international partners to accomplish its mission. Much has been accomplished, and much remains to be done. On 2 October 2008, this day-long conference brought together current and former senior officials and experts to help the defense threat reduction community to consider the lessons of the first decade and to offer ideas on how defense threat reduction can most effectively be pursued over the next ten years.