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Abstract
Grant Number: 1F31AT003023-01 Project Title: Beneficial Effects of Blueberries on Neural Transplants
PI Information: Name Title WILLIS, LAUREN M. willisl@musc.edu Abstract: DESCRIPTION (provided by applicant): The research application contained herein outlines a program of study to investigate the beneficial effects of dietary blueberry supplementation on survival of transplanted neural tissues. A unique technique of intraocular transplantation will be used to assess the survival of transplanted neural tissue in a middle- aged host with and without blueberry supplementation. Preliminary data completed previously indicates that dietary blueberry supplementation improves the ability of a middle- aged host animal to support graft survival and growth. The present application focuses on two possible paradigms by which blueberry supplementation improves graft survival: reduction of factors that inhibit graft survival, and promotion of factors that support graft survival. These studies encompass training in highly specialized techniques that are necessary for a competitive career in research. In addition, these experiments focus on nutritional intervention in improving survival of transplanted neural tissue to a middle-aged host animal, a new focus in the field of aging and alternative medicine.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
chemoprevention, dietary supplement, fruit, nervous system transplantation, plant extract, transplant rejection
aging, antioxidant, cytokine, eye transplantation, immunomodulator, intraocular fluid
alternative medicine, laboratory rat, mature animal, nutrition related tag, predoctoral investigator
Institution: MEDICAL UNIVERSITY OF SOUTH CAROLINA Office of Research and Sponsored Programs CHARLESTON, SC 29425 Fiscal Year: 2005 Department: NEUROSCIENCES Project Start: 01-AUG-2005 Project End: 31-JUL-2008 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1