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Abstract
Grant Number: 1R21AT002617-01A1 Project Title: Beneficial Metabolic Effects of Fasting
PI Information: Name Title DONAHOO, WILLIAM T. wdonahoo@uvm.edu Abstract: DESCRIPTION (provided by applicant): The both complementary and alternative medicine practice of therapeutic fasting is recommended as a treatment of obesity and other metabolic diseases. Obesity is currently the most significant nutritional disorder in the United States and a reduction in the prevalence of obesity is targeted as a major objective in "Healthy People 2010". However, despite these goals, the prevalence of obesity is continuing to rise. New treatment options for obesity are desparately needed. The weight loss and metabolic benefits of traditional caloric restriction tend to be small and short lived. There are strong data to support a variety of benefits and durability of weight loss with therapeutic fasting. However, persistent fasting is not practical and has increased associated adverse events. Recently, animal data suggests that intermittent fasting (every other day) has similar metabolic benefits to prolonged fasting. There are also data to suggest that intermittent fasting will be safer than prolonged fasting and easier to tolerate than traditional caloric restriction. The studies described herein are designed to test the overall hypothesis that therapeutic intermittent fasting (IF) will be a more effective treatment for obesity than moderate daily caloric restriction (CR). The following specific aims will be addressed: 1) To determine the effect of IF compared to CR on weight loss and body composition 2) To explore the effect of IF compared to CR on insulin sensitivity, lipid levels, and blood pressure 3) To evaluate the safety and tolerability of IF compared to CR Following baseline measurements, participants will be randomized to a standard caloric restriction diet or to intermittent fasting. Interim measures will be collected at one week, and follow up measures collected at eight weeks. Exploratory data will be collected at 20 and 32 weeks to evaluate the durability of the intervention and monitor long-term safety.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
alternative medicine, bioenergetics, diet route /schedule, fasting, human therapy evaluation, obesity, weight control
blood lipid, blood pressure, body composition, caloric dietary content, dietary restriction, insulin sensitivity /resistance, longitudinal human study, weight loss
clinical research, human middle age (35-64), human subject, nutrition related tag, patient oriented research, young adult human (21-34)
Institution: KAISER FOUNDATION RESEARCH INSTITUTE OAKLAND, CA 94612 Fiscal Year: 2005 Department: Project Start: 30-SEP-2005 Project End: 31-JUL-2007 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1