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Abstract
Grant Number: 1K23AT002965-01 Project Title: Diet and Stress Reduction in Recurrent Prostate Cancer
PI Information: Name Title SAXE, GORDON A. gsaxe@ucsd.edu ASSISTANT PROFESSOR Abstract: DESCRIPTION (provided by applicant): One man in six in the U.S. will develop prostate cancer in his lifetime, and about one third of treated patients will experience a relapse (marked by a rising PSA level) after surgery or radiation. While hormone therapy can temporarily palliate symptoms and may slightly extend survival in advanced disease, no curative therapy exists at this stage. However, a number of documented "best cases" provide evidence of remission of metastatic prostate cancer after adoption of plant-based diets, often in tandem with body-mind stress reduction approaches. A growing scientific literature suggests that dietary factors play an important etiological role, particularly in the later phases of tumor promotion and progression, perhaps mediated by endocrine or immune modulation. Our preliminary data suggest that an intensive program of diet modification, coupled with stress reduction to enhance dietary adherence and reduce anxiety, simultaneously reduces the rate of disease progression (as assessed by change in the rate of PSA increase), induces healthy weight reduction, and enhances quality of life in relapsed patients. The proposed career development award (CDA) incorporates, at its core, a research plan to build on these pilot data by conducting a larger and more rigorous randomized trial of this approach in recurrent prostate cancer. Other elements of the CDA include: (1) didactic coursework in behavioral modification, clinical trial design and conduct, database management, and ethical conduct of research; (2) hands-on experience in multicenter research by serving as a University of California, San Diego (UCSD) representative and Site Director for a CALGB cooperative group study of a similar diet-cancer intervention; (3) primary mentorship offering expertise and resources in behavior change as well as in multicenter diet and cancer intervention research; and (4) participation in a rich academic environment that provides access to extensive research resources offered by the UCSD Clinical Research Center, Cancer Center, and School of Medicine.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
diet, human therapy evaluation, neoplasm /cancer nutrition therapy, neoplasm /cancer relapse /recurrence, prostate neoplasm, stress management
anxiety, endocrinology, health behavior, neoplastic process, nutrition aspect of cancer, prostate specific antigen, quality of life, therapy compliance, weight loss
alternative medicine, clinical research, human subject, male, nutrition related tag
Institution: UNIVERSITY OF CALIFORNIA SAN DIEGO 9500 GILMAN DR, DEPT 0934 LA JOLLA, CA 920930934 Fiscal Year: 2005 Department: FAMILY AND PREVENTIVE MEDICINE Project Start: 01-SEP-2005 Project End: 31-AUG-2010 ICD: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE IRG: ZAT1