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Initiative for Vaccine Research (IVR) |
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Key documents
General
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IVR strategic plan 2006-2009 [pdf 390kb]
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State of the art of new vaccines: research and development REVISED 2005
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IVR Activities Report 2006 - 2007
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IVR Activities Report 2004 - 2005 [pdf 352kb]
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IVR Activities Report 2002-2003 [pdf 4.22Mb]
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Report of the Seventh Meeting of the IVR Vaccine Advisory Committee (IVAC), May 2008 [pdf 102kb]
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External Review of IVR 2007/2008 [pdf 653kb]
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Report on the overview of vaccine R&D in WHO and UNAIDS, June 1999 [pdf 261kb]
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Current Status of Vaccines in Development, February 2006 [pdf 85kb]
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Report on WHO Consultation on Viral Vectors, December 2003
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Assessing the global need for vaccine R&D, November 1999 [pdf 188kb]
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Today's challenges in vaccine R&D: WHO's perspective [offsite pdf]
Global Vaccine Research Forum Reports
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Proceeding of the Seventh Global Vaccine Research Forum and Parallel Satellite Symposia, 3-6 December 2006, Bangkok, Thailand
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Proceedings of the Sixth Global Vaccine Research Forum and Parallel Satellite Symposia, 12-15 June 2005, Salvador da Bahia, Brazil
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Proceedings of the Fifth Global Vaccine Research Forum, 7-10 June 2004, Montreux, Switzerland [pdf 515kb]
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Proceedings of the Fourth Global Vaccine Research Forum, 30 June - 2 July 2003, Seoul, Republic of Korea [pdf 247kb]
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Proceedings of the Third Global Vaccine Research Forum, Geneva, 9-11 June 2002 [pdf 240kb]
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Proceedings of the Second Global Vaccine Research Forum, Montreux, Switzerland, 10-12 June 2001 [pdf 221kb]
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Proceedings of the First Global Vaccine Research Forum, Montreux, Switzerland, 7-9 June 2000 [pdf 342kb]
Ethics
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Ethical considerations arising from vaccine trials
Bacterial diarrhoeal vaccines
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Generic protocol to estimate the burden of Shigella diarrhoea and dysenteric mortallity - Field test version, May 1999 [pdf 116kb]
Cholera
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Documents, publications, videos and papers
Dengue vaccines
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Report of the Steering Committee on Dengue and Other Flavivirus Vaccines including Minutes of the Steering Committee Meeting, April 2004 [pdf 176kb]
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Meeting of the WHO Task Force on Clinical Trials of Dengue Vaccines, Bangkok, Thailand, October 2004 [pdf 134kb]
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Minutes of the Informal Consultation on Antibody Protection against Dengue Infection, April 2003 [pdf 354kb]
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Meeting of the WHO Task Force on Clinical Trials of Dengue Vaccines. Washington DC, 11 December 2005
Enterotoxigenic Escherichia coli (ETEC)
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Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries, March 2006
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Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hly A), July 1998
Haemophilus influenzae (HiB)
Generic protocol for population-based surveillance of Haemophilus influenza type b, 1996 [pdf 129kb]
Human papillomavirus vaccines
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Report of the Consultation on Human Papillomavirus Vaccines, WHO HQ Geneva, April 2005 [pdf 271kb]
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Technical Workshop on International Collaborative Studies on HPV Reagents for Laboratory Diagnostic Procedures - A Progress report. October 2004 [pdf 9.17Mb]
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Assessment and harmonization of laboratory diagnostic procedures related to human papillomavirus vaccine research and development. Report of a technical meeting, March 2001 [pdf 150kb]
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The current status of prophylactic vaccines against human papillomavirus infection, February 1999 [pdf 85kb]
influenza
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Business Plan for the Global Pandemic Influenza Action Plan to Increase Vaccine Supply [pdf 1.22Mb]
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Development and evaluation of influenza pandemic vaccines: report of WHO expert meeting, 2-3 November 2005 [pdf 45kb]
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Development of influenza vaccines with broad spectrum and long-lasting immune responses, February 2004
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The report of the meeting with International Partners on Influenza Vaccine technology Transfer to Developing Country Vaccine Manufacturers f
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The report of the First meeting of the Global Action Plan (GAP) to Increase Supply of Pandemic Influenza Vaccines
Japanese encephalitis vaccines
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Report of the Steering Committee on Dengue and Other Flaviviruses Vaccines, April 2003 [pdf 422kb]
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Guidelines for the clinical evaluation of dengue vaccines in endemic areas
Malaria vaccines
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Candidate malaria vaccines in clinical development, October 2008 [pdf 47kb]
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Candidate malaria vaccines in pre-clinical development, October 2008 [pdf 122kb]
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Evaluation of Malaria Vaccines: Clinical Evaluation Group, Malaria Vaccine Advisory Committee (MALVAC) Meeting, October 2004 [pdf 504kb]
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Evaluation of Malaria Vaccines: Pre-clinical Evaluation Group, Malaria Vaccine Advisory Committee (MALVAC) Meeting, October 2004 [pdf 529kb]
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Malaria Transmission blocking vaccines: an ideal public good, 2000 [new window]
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Guidelines for the evaluation of Plasmodium falciparum vaccines in populations exposed to natural infection, 1997 [new window]
Measles
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Measles Strategic Plan 2001-2005 [new window]
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Measles Technical Working Group: strategies for measles control and elimination, Meeting Report, May 2000 [pdf 135kb]
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An overview of aerosol immunization [pdf 834kb]
Meningococcal vaccines
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Minutes of Informal Consultation on Meningococcal Carriage Studies in Africa, 23 September 2005, WHO HQ Geneva [pdf 522kb]
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Standardization and validation of serologic assays for the evaluation of immune responses to Neisseria meningitidis serogroup A/C vaccines, March 1999 [pdf 407kb]
Pneumococcal and other ARI vaccines
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Development of influenza vaccines with broad spectrum and long-lasting immune responses, February 2004
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Standard methods for collection and testing of nasopharyngeal specimens, Journal of Pediatric Infectious Diseases, 2003 [pdf 483kb]
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Protein and Other New Approaches to Vaccination Against Streptococcus pneumoniae, November 2001 [pdf 110kb]
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Generic protocol for population-based surveillance of haemophilus influenzae type b, 1996 [pdf 129kb]
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Generic protocol to examine the incidence of lower respiratory infection due to respiratory syncytial virus in children less than five years of age - Field test version, 2000 [pdf 140kb]
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Standard interpretation of chest radiographs for the diagnosis of pneumonia in children, October 2001 [pdf 143kb]
Rabies
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Use of mouse anti-rabies monoclonal antibodies in post-exposure treatment of rabies, September 1989 [new window]
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Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system, August 1992 [new window]
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Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis, July 2001 [new window]
Rotavirus vaccines
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Guidelines for estimating the economic burden of diarrhoeal disease with focus on assessing the cost of rotavirus diarrhoea, November 2005 [pdf 723kb]
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Rotavirus Vaccines - an update, WHO Weekly Epidemiological Record, 2003: 78: 1-8
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Report of the meeting on future directions for rotavirus vaccine research in developing countries, February 2000 [pdf 175kb]
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Acute intussusception in infants and children - Incidence, clinical presentation and management: A global perspective, October 2002 [pdf 312kb]
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Generic protocols (i) hospital based surveillance to estimate the burden of rotavirus gastro-enteritis in children and (ii) a community based survey on the utilisation of health care services for gastro-enteritis in children, November 2002 (Eng) [pdf 1.4mb]
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Generic protocols (i) hospital based surveillance to estimate the burden of rotavirus gastro-enteritis in children and (ii) a community based survey on the utilisation of health care services for gastro-enteritis in children, November 2002 (Fre) [pdf 354kb]
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Generic protocols (i) hospital based surveillance to estimate the burden of rotavirus gastro-enteritis in children and (ii) a community based survey on the utilisation of health care services for gastro-enteritis in children, November 2002 (Russian) [pdf 720kb]
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Rotavirus Vaccines - WHO Position Paper, Weekly Epidemiological Record, 1999: 74: 33-40
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Vaccine Research and Development - Rotavirus vaccines for developing countries, WHO Weekly Epidemiological Record, 1997: 72: 33-40
SARS
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Report on WHO consultation on needs and opportunities for SARS vaccine research and development, October 2003 [pdf 132kb]
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Report of International workshop on development of vaccines for SARS and new human influenza vaccines, March 2004 [pdf 141kb]
Shigellosis
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Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries, February 2006
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Shigellosis: disease burden, epidemiology and case management, WHO Weekly Epidemiological Record, 2005: 11: 93-100
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Guidelines for the control of shigellosis, including epidemics due to Shigella dysenteriae type 1 (2005) [pdf 1.15Mb]
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Antibiotics in the management of shigellosis, WHO Epidemiological Record, 2004: 39: 349-356
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Guidelines for the control of epidemics due to Shigella dysenteriae type 1, Geneva WHO, 1995
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New Strategies for accelerating Shigella vaccine development, WHO Weekly Epidemiological Record 1997; 72: 73-80 [pdf 188kb]
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Generic protocol to estimate the burden of Shigella diarrhoea and dysenteric mortality - Field test version (1999) [pdf 114kb] [pdf 116kb]
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New Strategies for accelerating Shigella vaccine development. WHO Weekly Epidemiological Record 1997; 72: 73-80 [pdf 188kb]
Tuberculosis vaccines
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Issues relating to the use of BCG in immunization programmes: a discussion document, 1999 [pdf 156kb]
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Report of the meeting of the working group on clinical trials of new TB vaccines, April 1999 [pdf 113kb]
Typhoid
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Diagnosis, treatment, prevention and epidemic preparedness of typhoid fever, May 2003 [pdf 272kb]
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Typhoid vaccines, WHO Epidemiological Record, 2000: 75: 257-264
Please note: this page lists documents that are highly relevant to international vaccine R&D efforts in the above diseases. While most were prepared by, or incollaboration with staff of the Vaccine R&D Teams in the WHO Department of Immunization, Vaccines and Biologicals, some were prepared, in part or in their entirety by other WHO entities and/or authors who are not WHO staff. The collaboration of the latter is gratefully acknowledged.
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