Paul M. Coates, Ph.D., Director, ODS
Biography
Paul M. Coates, Ph.D. was appointed Director of the Office of Dietary
Supplements (ODS) at the NIH effective October 25, 1999. He served from
1996-1999 as Deputy Director of the Division of Nutrition Research Coordination
(DNRC) at the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK). In that role, Dr. Coates helped to coordinate human nutrition
research efforts, both at the NIH and between the NIH and other government
agencies. Among these efforts was Healthy
People 2010, the initiative from the U.S. Department of Health and
Human Services (DHHS) to set public health goals for the nation.
Dr. Coates co-leads the development of the Nutrition/Overweight chapter
for which he received the NIH Director's Award for outstanding activities. Dr.
Coates acted as Co-Chair of the joint DHHS/USDA Steering Committee overseeing
plans for the National Nutrition Summit that was held in Washington in May 2000.
He also is a member of the Federal Steering Committee that oversees the development
of the Dietary Reference Intakes.
Prior to joining the DNRC, Dr. Coates was NIDDK's Program Director for
the Type 2 Diabetes Research Program (1993-1996) and Project Officer for
the multi-center clinical study called Epidemiology of Diabetes Interventions
and Complications (1994-1996). From 1994 until his departure from
NIDDK, he maintained an active interest in career development and fellowship
training in the Division of Diabetes, Endocrinology, and Metabolic Diseases.
Before coming to the NIH, Dr. Coates was on the faculty of the University
of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia
(1975-1993), where he was Research Professor in the Departments of Pediatrics
and Biochemistry/Biophysics. His Ph.D. degree in human genetics was
from Queen's University in Canada (1972) and his postdoctoral training
took place in the Department of Human Genetics and Biometry at University
College London (1972-1974).
His major research interests for many years focused on inborn errors
of human lipid metabolism. Dr. Coates conducted some of the early studies
of fatty acid oxidation disorders in infants and children. With an international
team of collaborators, he was responsible for defining many of the genetic
defects of human mitochondrial fatty acid oxidation. He also has
studied the metabolism of intestinal and hepatic lipoproteins in people,
to identify the metabolic defects in inherited hyperlipidemias. These
studies have led to a new understanding of the role of environmental factors,
such as diet, in the manifestation of genetic disease. He has written
more than 100 publications, and has edited two books in these areas of
research.
Congressional Testimony
Selected References
1. Tanaka K, Coates PM (editors): Fatty Acid Oxidation: Clinical,
Biochemical, and Molecular Aspects. New York: Alan R Liss, 1990.
2. Coates PM, Tanaka K (editors): New Developments in Fatty Acid
Oxidation. New York: Wiley-Liss, 1992.
3. Coates PM, Tanaka K: Molecular basis of mitochondrial fatty acid
oxidation defects. J Lipid Res 33: 1099-1110, 1992.
4. Cortner JA, Le N-A, Coates PM, Bennett MJ, Cryer DR: Determinants
of fasting plasma triglyceride levels: metabolism of hepatic and intestinal
lipoproteins. Eur J Clin Invest 22: 158-165, 1992.
5. Cortner JA, Coates PM, Liacouras CA, Jarvik GP: Familial combined
hyperlipidemia in children: Clinical expression, metabolic defects and
management. J Pediatr 123: 177-184, 1993.
6. Pairitz Jarvik G, Beaty TH, Gallagher PR, Coates PM, Cortner JA:
Genotype at a major locus with large effects on apolipoprotein B levels
predicts familial combined hyperlipidemia. Genet Epidemiol 10: 257-270,
1993.
7. Anderson RA, Byrum RS, Coates PM, Sando GN: Mutations at the lysosomal
acid cholesteryl ester hydrolase gene locus in Wolman disease. Proc
Natl Acad Sci USA 91: 2718-2722, 1994.
8. Coates PM: New developments in the diagnosis and investigation of
mitochondrial fatty acid oxidation disorders. Eur J Pediatr 153 (suppl
1): S49-S56, 1994.
9. Hayman LL, Meininger JC, Coates PM, Gallagher PR: Nongenetic influences
of obesity on risk factors for cardiovascular disease during two phases
of development. Nursing Res 44: 277-283, 1995.
10. Roe CR, Coates PM: Mitochondrial fatty acid oxidation disorders.
In: The Metabolic and Molecular Bases of Inherited Disease (Scriver
CR, Beaudet AL, Sly WS, Valle D, eds), 7th edition. New York: McGraw-Hill,
1995, pp 1501-1533.
11. Coates PM, Cortner JA: Lysosomal acid lipase deficiency: Cholesteryl
ester storage disease and Wolman disease. In: Pediatric Gastrointestinal
Disease (Walker WA, Durie PR, Hamilton JR, Walker-Smith JA, Watkins JB,
eds), 2nd edition. Philadelphia: CV Mosby, 1996, pp 1155-1163.
12. Coates PM: Inherited abnormalities in mitochondrial fatty acid oxidation.
In: Pediatric Gastrointestinal Disease (Walker WA, Durie PR, Hamilton
JR, Walker-Smith JA, Watkins JB, eds), 2nd edition. Philadelphia: CV Mosby,
1996, pp 1163-1181.
13. Cortner JA, Coates PM, Tershakovec AM: Disorders of lipoprotein
metabolism and transport. In: Nelson Textbook of Pediatrics
(Behrman RE Jr, ed), 15th edition. Philadelphia: WB Saunders, 1996, pp
377-385.
14. Le N-A, Coates PM, Gallagher PR, Cortner JA: Kinetics of retinyl
esters during postprandial lipemia in man: A compartmental model.
Metabolism 46: 584-594, 1997.
15. Dixon LB, Shannon BM, Tershakovec AM, Bennett MJ, Coates PM, Cortner
JA: Effects of family history of heart disease, apolipoprotein E phenotype,
and lipoprotein (a) on the response of children's plasma lipids to change
in dietary lipids. Am J Clin Nutr 66: 1207-1217, 1997.
16. Meininger JC, Hayman LL, Coates PM, Gallagher PR: Genetic and environmental
influences on cardiovascular disease risk factors in adolescents.
Nursing Res 47:11-18, 1998.
17. Coates PM: Fatty acid metabolism in mitochondria: defects and genetics.
BioFactors 7: 201-202, 1998.
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