Formylpeptide Receptor (FPR) as a Target for Anti-Malignant Glioma Therapy
Description of Invention:
The present invention identifies formylpeptide receptor (FPR) as a target for therapeutic intervention against malignant gliomas. More specifically, the invention describes a method for inhibiting a FPR-mediated activity of a glioma cell expressing FPR, comprising contacting the cell with an effective amount of an agent that inhibits expression and/or activity of the FPR. Several classes of inhibitors of FPR expression and/or activity are shown to inhibit glioma cells, in particular, small interfering RNAs (siRNAs) and small molecule antagonists of FPR.
In addition to disclosing inhibitory agents for carrying out this method, the invention also discloses diagnostic methods for identifying highly malignant glioma cells and a method for identifying an agent that inhibits an FPR-mediated activity of a glioma cell.
Inventors:
Ji Ming Wang et al. (NCI)
Patent Status:
DHHS Reference No. E-069-2004/0 Licensing Status: This technology is no longer available for licensing.
Portfolios: Cancer
Cancer -Diagnostics Cancer -Therapeutics
For Additional Information Please Contact: Jasbir (Jesse) S. Kindra J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5559
Email: kindraj@mail.nih.gov
Fax: (301) 402-0220
