Description of Invention:
The invention is a method for preventing venous access device (VAD) thrombosis by coating the VAD catheter with lepirudin, which has been found to be readily adsorbed by the silicone rubber of the VADs, and is expected to have good retention properties. VADs typically remain in place for weeks or months and sometimes cause clotting (thrombosis) of the veins. Accordingly, the simple technique of soaking a silicone catheter in lepirudin before venous insertion is the gist of the invention. Chronically ill patients who must be catheterized for long periods of time will benefit particularly from this technique which promises to reduce swelling and pain associated with VAD-induced thrombosis.
Inventors:
McDonald Horne (CC)
Patent Status:
DHHS Reference No. E-295-2002/0 --
U.S. Provisional Application No. 60/436,439 filed 23 Dec 2002
PCT Application No. PCT/US03/40888 filed 22 Dec 2003, which published as WO 2004/058324 A2 on 15 Jul 2004
Relevant Publication:
MK Horne, KJ Brokaw, "Antithrombin activity of lepirudin adsorbed to silicone (polydimethylsiloxane) tubing," Thrombosis Research (2003) 112:111-115.
Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Portfolios: Devices/Instrumentation
Devices/Instrumentation-Therapeutics-Devices-Methods of Using Devices Devices/Instrumentation-Therapeutics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
