Method for Preparing 17alpha-acetoxy-11beta-(4,N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, Intermediates Thereof, and Methods for the Preparation of Such Intermediates
Description of Invention:
The compound 17alpha-acetoxy-11beta-(4-N,N-dimethylamino-phenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914) is a well known steroid which possesses antiprogestational and antiglucocorticodal activity. CDB-2914 could be used in contraception and therapeutic applications, including fibroids and endometriosis. The NIH announces improvements in the process of producing CDB-2914. The new process shortens the overall number of synthetic steps from seven to five and shows an improvement in yield from 13% to 20%.
Inventors:
H.K. Kim et al. (NICHD)
Patent Status:
DHHS Reference No. E-113-2002/0 --
U.S. Provisional Application No. 60/451,096 filed 28 Feb 2003
PCT Application No. PCT/US2004/04246 filed 13 Feb 2004, which published as WO 2004/078709 on 16 Sep 2004
U.S. Patent Application No. 10/542,580 filed 19 Jul 2005
Relevant Publication: Rao PN, Acosta CK, Bahr ML, Burdett JE, Cessac JW, Morrison PA, and Kim HK; A practical large-scale synthesis of 17alpha-acetoxy-11beta-(4-N,N-dimethylamino-phenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914); Steroids 65 (2000), 395-400.
For Additional Information Please Contact: Tara L. Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4426
Email: tarak@mail.nih.gov
Fax: (301)402-0220
