Method and Materials for Promoting Migration of T-Cells to the Vasculature of a Tumor
Description of Invention:
Adoptive immunotherapy with T cells is a promising therapeutic modality for cancer. However, the effectiveness of this method of treatment appears to be limited by the inefficient migration of T cells to the tumor site. The present invention provides materials and methods that promote the migration of T cells to the vasculature of a tumor.
This invention discloses a novel method of administering modified autologous T cells, which bind to cell-surface molecules on endothelial cells of the vasculature of a tumor. Using the disclosed method and modified T cells, investigators were able to promote the migration of T cells to molecules expressed on the vasculature of tumors. It is anticipated that this method and these modified autologous T cells will improve the effectiveness of adoptive immunotherapy for a variety of tumors, including melanoma and many carcinomas and sarcomas.
Inventors:
Patrick Hwu and Mary Tschoi (NCI)
Patent Status:
DHHS Reference No. E-082-2003
Relevant Publication:
Dudley et al., "Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes", Science Oct 25 2002: 850-854. Published online September 19, 2002; 10.1126/science.1076514 (Science Express Reports)
Licensing Status: This technology is no longer available for licensing.
Portfolios: Cancer
Cancer -Therapeutics-Immunomodulators and Immunostimulants Cancer -Therapeutics
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