Description of Invention:
This technology pertains to the discovery of a new member of the ING (inhibitor growth) family of putative tumor suppressor genes, p28ING5. p28ING5 was identified by homology to the tumor suppressor gene p33ING1. Over-expression of the ING5 protein causes cell cycle arrest in human cancer cell lines and ING5 expression varies between cancer cell lines. Detection of ING5 gene or protein expression could potentially be used for cancer diagnosis and ING5 could be used as a medicant.
Inventors:
Dr. Curtis C. Harris et al. (NCI)
Patent Status:
DHHS Reference No. E-300-2001/0 --
U.S. Provisional Application No. 60/351,504 filed 23 Jan 2002
PCT Application No. PCT/US03/02174 filed 23 Jan 2003, which published as WO 03/062398 on 23 Jul 2003
U.S. Patent Application No. 10/502,431 filed 22 Jul 2004
Portfolios: Cancer
Cancer -Diagnostics Cancer -Therapeutics
For Additional Information Please Contact: Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)435-4633
Email: wongje@mail.nih.gov
Fax: (301)402-0220
