Compositions and Methods for the Diminution or Elimination of Various Cancers
Description of Invention:
This invention relates to the use of antisense technology to inhibit JNK2 expression as a novel methodology for cancer treatment. Inhibition of JNK2 expression by JNK2 antisense oligonucleotide (JNK2AS) has produced inhibition of tumor cell growth and induction of an apoptotic response in a p53-related manner, with p53-deficient cells being more sensitive.
