Description of Invention:
This invention described and claimed in this patent application provides for an improved method for producing human growth hormone (hGH) in vitro or in vivo. In particular, the patent application describes compositions and methods which are based on a modified form of human growth hormone where the regulated secretory pathway (RSP) sorting signal has been modified to provide for the constitutive secretion of human growth hormone via the nonregulated secretory pathway (NRSP) in a mammalian cell. One particular modified hGH composition, has been demonstrated to be biologically active and able to be secreted into the bloodstream in an animal model providing proof-of-concept. This invention can be applied to a non-invasive method of gene therapy to achieve sustained delivery of this therapeutic protein.
The application has been published as WO 02/092619 (11/21/2002) and as 2004/0158046 A1 (08/12/2004). The work has also been published at Wang J, et al Human Gene Therapy 16(5):571-83 (May 2005). Only U.S. Patent protection has been sought for this technology. There are no foreign counterpart patent applications.
Inventors:
YP Loh and NX Cawley (both of NICHD) BJ Baum (NIDCR) and CR Snell
Patent Status:
DHHS Reference No. E-184-2001/1 --
U.S. Patent Application No. 10/477,651 filed 14 Nov 2003, which is a 371 application of PCT/US02/15172 filed 14 May 2002 and which claims priority to 60/290,836 filed 14 May 2001
Licensing Status: Available for non-exclusive or exclusive licensing.
In addition, the NICHD Office of the Scientific Director is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the non-invasive method of production and systemic delivery of growth hormone or other proteins for therapeutic purposes. Please contact Dr. Y. Peng Loh at 301/496-3239 or lohp@mail.nih.gov for more information.
Portfolios: Gene Based Therapies
Gene Based Therapies -Therapeutics-Gene Therapy-Vectors-Control sequences/genes Gene Based Therapies -Therapeutics-Gene Therapy-Vectors Gene Based Therapies -Therapeutics-Gene Therapy-Therapeutic Genes Gene Based Therapies -Therapeutics-Gene Therapy-Delivery Systems Gene Based Therapies -Therapeutics-Gene Therapy Gene Based Therapies -Therapeutics
For Additional Information Please Contact: Susan S. Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4478
Email: ruckersu@mail.nih.gov
Fax: (301) 402-0220
