Pressure Mediated Selective Delivery Of Therapeutic Substances
Description of Invention:
The present application describes a system and method for improved regional, organ, tissue, tissue-compartment, and celltype-specific delivery of therapeutic agents via infusion of those agents into body lumens under controlled pressure and volume conditions. Methods of varying the pressure and flow rates for given body targets and depths are also disclosed along with methods of determining the proper protocol for a given target tissue. This application also includes designs for access cannulas, catheters, access ports, and other devices for controlled, targeted delivery of therapeutic agents, including drugs and gene therapy vectors. Local administration of drugs, gene therapy vectors, and other therapeutic agents in accordance with this invention can permit organ, tissue, tissue-compartment, and celltype-specific delivery, thereby maximizing administration to intended tissue targets using therapeutically effective dosages while simultaneously reducing the risk of systemic delivery and toxicity.
Inventors:
SM Wiener (NHLBI) RF Hoyt (NHLBI) JR DeLeonardis (NHLBI) RR Clevenger (NHLBI) RJ Lutz (NHLBI) B Safer (NHLBI)
Patent Status:
DHHS Reference No. E-196-1998/0 --
U.S. Provisional Application No. 60/086,565 filed 21 May 1998
DHHS Reference No. E-196-1998/1 --
U.S. Provisional Application No. 60/087,999 filed 28 May 1998
DHHS Reference No. E-196-1998/2 --
PCT Application No. PCT/US99/11277 filed 21 May 1999, which published as WO 99/59666 on 25 Nov 1999
U.S. Patent Application No. 09/700,999 filed 04 Dec 2000
Licensing Status: Please view the record for DHHS Reference No. E-196-1998/2 ("Cannula for Pressure Mediated Drug Delivery") for an updated version of this licensing opportunity.
Portfolios: Devices/Instrumentation
Devices/Instrumentation-Therapeutics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
