Thymosin alpha 1 Promotes Tissue Repair, Angiogenesis and Cell Migration
Description of Invention:
These applications describe the use of the compound thymosin alpha 1 as an agent for promoting wound healing. Thymosin alpha 1 is a small, 28 mer, peptide which can be made by chemical synthesis or recombinantly. Studies using a punch model for wounds in rats have shown that providing thymosin alpha1 either intraperitoneally or topically accelerates wound healing. In addition, thymosin alpha 1 has been shown to promote endothelial and keratinoctye cell migration in vivo and to promote angiogenesis in vivo.
Inventors:
KM Malinda (NIDCR) HD Kleinman (NIDCR) et al.
Patent Status:
DHHS Reference No. E-250-1997/1 --
U.S. Patent No. 6,197,751 issued 06 Mar 2001
Relevant Publication: This work has been published in J. Immunol. 160(2): 1001-6 (Jan 15, 1998).
