Antipsychotic Composition And Method For Treatment
Description of Invention:
This invention comprises a novel treatment method for patients suffering from serious psychotic mental illness that offers to significantly improve the treatment of such illnesses. Conventional antipsychotic drugs are effective in improving symptoms of schizophrenia, but a significant number of patients have proven resistant to such treatments. Recently, the drug clozapine has been found effective in treating such drug-resistant patients; however, clozapine has severe toxic side effects. This newly developed treatment method, which combines the use of an a2-adrenergic receptor antagonist with a standard antipsychotic drug, is effective in treating psychosis without serious side effects. It is especially effective in patients who previously had been resistant to treatment with standard antipsychotic drugs alone.
Inventors:
D Pickar RE Litman WZ Potter (NIMH)
Patent Status:
DHHS Reference No. E-051-1993/1 Licensing Status: This technology is no longer available for licensing.
Portfolios: Central Nervous System
Central Nervous System -Therapeutics-Psychotherapeutics-Antipsychotics Central Nervous System -Therapeutics
For Additional Information Please Contact: Norbert J. Pontzer PhD JD
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5502
Email: pontzern@mail.nih.gov
Fax: (301) 402-0220
