Integrated Low Field MRI/RF EPRI for Co-Registering Imaging of In Vivo Physiology and Anatomy in Living Objects
Description of Invention:
Obtaining physiological information in a non-invasive manner from living tissue will provide valuable information, rather than invasive methods that are sometimes not available and also may damage living tissue. EPRI (Electron Paramagnetic Resonance Imaging) is the technique to investigate physiological information such as oxygen imaging and pharmacokinetic imaging in a non-invasive manner after non-toxic infusion of the spin probe.
However, the disadvantage of EPRI is the lack of proper orientation of the physiological image with respect to anatomy. On the contrary, Magnetic Resonance Imaging (MRI) methods are excellent for providing images with fine anatomical detail, but are often not possible methods that provide physiological information co-registered with anatomy with clinically relevant resolution.
However, the disadvantage of EPRI is the lack of proper orientation of the physiological image with respect to anatomy. On the contrary, Magnetic Resonance Imaging (MRI) methods are excellent for providing images with fine anatomical detail, but are often not possible methods that provide physiological information co-registered with anatomy with clinically relevant resolution.
Therefore, the EPR images contain spectral information regarding the local physiological conditions such as oxygen status. This data, when overlaid with anatomical images of MRI (Magnetic Resonance Imaging), co-register anatomical MR images and EPR physiological images.
Inventors:
Murali K. Cherukuri et al. (NCI)
Patent Status:
DHHS Reference No. E-120-99/0 filed 01 Nov 1999
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
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Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
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