Ribonuclease H1 - A Protein Expressed in Escherichia coli from a Cloned Human RNase H1 cDNA
Description of Invention:
Available for licensing through a Materials License Agreement (no patent or patent application) are samples of purified human RNase H1 protein, expressed in E. coli from human RNase H1 cDNA. This protein is important for cellular functions such as DNA synthesis and repair. This protein also is related by sequence, structure and enzymatic mechanism to the RNase H of retroviruses such as HIV. Since the cellular and viral proteins have similar properties, it would be useful to screen for potential drugs that have little or only modest effects on the cellular protein while inhibiting the HIV enzyme. Thus, the availability of both the retroviral and human RNases H1 makes drug screening and anti-sense therapy possible to perform.
Inventors:
Robert J. Crouch Susana Cerritelli Sergey Gaidamakov and Hirofumi Yamada (NICHD)
Patent Status:
DHHS Reference No. E-047-01/0
Portfolios: Infectious Diseases Gene Based Therapies
Gene Based Therapies -Therapeutics-Oligonucleotide Based Therapies-Antisense Gene Based Therapies -Therapeutics Infectious Diseases -Therapeutics
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
