Association of the ECHDCI/RNF146 Gene Region on Human Chromosome 6q with Breast Cancer Risk and Protection
Description of Invention:
The technology describes a genetic locus (ECHDC l/RNF146 gene region on human chromosome 6q) that may be predictive for risk of breast cancer in relatives of individuals diagnosed with breast cancer. Furthermore, the invention provides evidence that one or more polymorphism alleles in chromosome 6q22.33 indicates a lower risk or increased risk of developing breast cancer in individuals.
Applications:
The invention has the potential of being developed into a predictive diagnostic test, for people at a risk of breast cancer, together with other risk factors for the disease, such as age, parity, and other genetic contributions especially for predicting risk of breast cancer in individuals free of BRCA1 and BRCA2 polymorphism.
The invention may help to develop pharmaceuticals through elucidation of the contributing biochemical, etiologic pathway.
Advantages:
This study was a clinical study in a cohort of individuals. Thus the relevance of the data is of considerable significance.
Development Status:
Validation of the correlation between the polymorphisms and risk of breast cancer is ongoing using different cohorts.
