Description of Invention:
This technology relates to the use of substituted or modified C60 fullerenes, which are carbon-based molecular cages that resemble soccer balls, for the prevention or treatment of thrombosis, peripheral arterial occlusion, and catheter obstruction. Described are compositions and methods for administering such compounds at the implantation site of an in-dwelling device and methods of coating in-dwelling devices with such compounds. Such devices include stents, stent grafts, pacemakers, defibrillators, venous valves, heart valves, sutures, catheters, and drug delivery ports.
Applications:
Non-invasive method of preventing clot formation.
Market:
Anticoagulation therapy averages several billion dollars a year.
Further Research Required:
Anti-coagulant properties of C-60 derivatives in vivo
Device coating and in vivo efficacy
Safety evaluation of device, in vivo models
Inventors:
Marina Dobrovolskaia et al. (NCI)
Patent Status:
DHHS Reference No. E-140-2006/0 --
PCT Application No. PCT/US2006/041838 filed 25 Oct 2006, which published as WO 2008/063157 on 29 May 2008
For Additional Information Please Contact: Fatima Sayyid M.H.P.M.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4521
Email: sayyidf@mail.nih.gov
Fax: (301) 402-0220
