Description of Invention:
The current technology represents a potentially safe and effective addition to the antiretroviral drug combinations used for treatment of HIV infection. Amifostine, phosphonol and functional derivatives thereof are available for licensing and commercial development for use as antiretroviral drugs. These organic thiophosphate reducing agents inhibit HIV viral growth and protein expression in HIV-infected human white blood cells without destroying the cells. The compounds described in this technology block growth of HIV by a mechanism that is dependent on the level of aminothiol reducing agent in the cellular environment. In addition, a range of effective doses and methods for oral administration of the available organic thiophosphates is provided.
Applications:
Novel therapeutics for the treatment of HIV infection
Safe and effective addition to the drug combinations currently used to treat HIV/AIDS
Market:
Nearly 40.3 million people living with HIV worldwide, including approximately 2.0 million people in North America and Europe
Anti-HIV/AIDS therapeutics experience accelerated market acceptance and draw revenues of approximately $240 million to $1 billion
Development Status:
Preclinical data is available at this time.
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NP Nguyen, B Levinson, S Dutta, U. Karlsson, KC Kelly, J Dowell, A Ludin, S Sallah. Amifostine and curative intent chemoradiation for compromised cancer patients. Anticancer Res. 2003 Mar-Apr; 23(2C):1649-1656. [PubMed abs]
Licensing Status: Available for non-exclusive or exclusive licensing.
Collaborative Research Opportunity:
The National Cancer Institute Laboratory of Cellular Carcinogenesis and Tumor Promotion is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize these organic thiophosphate antiretroviral agents. Please contact Betty Tong, Ph.D. at 301-594-4263 or tongb@mail.nih.gov for more information.
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
