Description of Invention:
This invention is an enzyme-linked immunosorbent assay (ELISA) to detect humoral immunity response to papillomavirus infection in humans and other vertebrates. Assays have thus far been produced based upon serum immunoglobulin recognition of conformational epitopes of papillomavirus virion proteins on purified virus-like particles for HPV16, which is the HPV type most frequently found in cervical cancer. Assays for other high-risk cervical cancer HPV types (HPV18, HPV31, and HPV45) and for low-risk genital HPV types (HPV6 and HPV11) are under development using the same technology. The ELISA test for the genital HPV types may be useful as an adjunct to the Papanicolaou (PAP) test for identifying women with an increased risk of developing cervical cancer.
Inventors:
Douglas R. Lowy (NCI) John T. Schiller (NCI) Reinhard Kirnbauer (NCI)
Patent Status:
U.S. Patent 5,437,951 issued 01 Aug 1995 (DHHS Reference No. E-253-1993/0-US-01)
U.S. Patent 5,756,284 issued 26 May 1998 (DHHS Reference No. E-253-1993/0-US-02)
U.S. Patent 5,709,996 issued 20 Jan 1998 (DHHS Reference No. E-253-1993/0-US-03)
U.S. Patent 5,871,998 issued 16 Feb 1999 (DHHS Reference No. E-253-1993/0-US-04)
U.S. Patent 5,744,142 issued 28 Apr 1998 (DHHS Reference No. E-253-1993/0-US-05)
U.S. Patent 5,716,620 issued 10 Feb 1998 (DHHS Reference No. E-253-1993/0-US-06)
U.S. Patent 5,985,610 issued 16 Nov 1999 (DHHS Reference No. E-253-1993/0-US-07)
U.S. Patent Application No. 09/316,487 filed 21 May 1999 (DHHS Reference No. E-253-1993/0-US-08)
U.S. Patent Application No. 10/371,846 filed 21 Feb 2003 (DHHS Reference No. E-253-1993/0-US-10)
Portfolios: Infectious Diseases Cancer
Cancer -Diagnostics-In Vitro-Other Infectious Diseases -Diagnostics-Viral-Non-AIDS (only) Cancer -Diagnostics Cancer -Therapeutics Cancer -Research Materials Infectious Diseases -Diagnostics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
