Description of Invention:
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne public health concern in many regions of the world including Africa, the Middle East, Europe, and Western Asia. The disease is etiologically linked to Crimean-Congo hemorrhagic fever virus (CCHFV) from the Nairovirus genus of the Bunyaviridae family of viruses and is transmitted primarily through the bite of Ixodid ticks. Available for licensing and commercial development are antigens, immunogens, and nucleic acid constructs for the development of vaccines against CCHFV. The antigens and immunogens are peptides corresponding to the soluble ectodomains of CCHFV G1 (Gc) and G2 (Gn) glycoproteins. Also provided are coupled proteins that include soluble peptide fragments derived from the G1 (Gc) or G2 (Gn) ectodomains or portions thereof; peptidomimetics; vaccines; immunogenic compounds methods for vaccination and inhibitors of CCHFV cell entry. Expression vectors and DNA vaccines encoding these peptides are also within the scope of the invention as well as antibodies, aptamers and kits containing antibodies or aptamers that bind to these peptides. CCHFV has been implicated as a pathogen of biodefense significance.
Inventors:
Dimiter Dimitrov and Xiadong Xiao (NCI)
Patent Status:
DHHS Reference No. E-299-2004/0-US-01 -- U.S. Provisional Application No. 60/624,783 filed 03 Nov 2004
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
