3-Deazaneplanocin, Intermediates for It, and Antiviral Composition and Method of Treatment Using It
Description of Invention:
This invention relates to antiviral and cancer chemotherapy and, more particularly, to the compound 3-deazaneplanocin A, and related compounds. It describes a method of preparation thereof, as well as the methods of preparation of a great variety of unsaturated (cyclopentenyl) carbocyclic nucleosides involving nucleophilic substitution. 3-deazaneplanocin A has been shown to have potent anti-viral, anti-tumor activity, as well as differentiating activity.
Potential Area of Application:
This invention can be used in treating viral diseases wherein the viruses causing the viral diseases require a methylated 5'-cap structure on their m-RNA.
Inventors:
Victor E. Marquez et al. (NCI)
Patent Status:
DHHS Reference No. E-493-1985/0 --
U.S. Patent No. 4,968,690 issued on 06 Nov 1990
DHHS Reference No. E-493-1985/1 --
U.S. Patent No. 4,975,434 issued on 04 Dec 1990
Portfolios: Infectious Diseases Cancer
Cancer -Therapeutics Infectious Diseases -Therapeutics
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
