Methods for Reducing Tumor Growth and Metastasis by Inhibiting MCP-1 Activity
Description of Invention:
Monocyte Chemotactic Protein 1 (MCP-1) is a chemokine that is abundantly produced in a variety of inflammatory diseases. Consistent with its role in inflammation, MCP-1 is known to be chemotactic for monocytes, T lymphocytes, basophiles and NK cells.
Based on its chemotactic effect on monocytes, MCP-1 has been observed to have an anti-tumor effect in certain mouse/tumor experimental designs. In those mouse systems, MCP-1 production by tumor cells was positively correlated with the number of intratumoral macrophages and inversely correlated with tumor growth. These studies have led to the hypothesis that MCP-1 possesses anti-tumorigenic activity.
The present invention is based on the surprising discovery that inhibition of MCP-1 activity inhibits tumor metastasis and prolongs survival. Accordingly, this invention generally relates to methods of inhibiting tumor growth and/or metastasis in a subject, and methods of treating cancer and/or increasing survival of a subject with a tumor, by inhibiting MCP-1 activity in the subject.
Inventors:
William J. Murphy et al. (NCI)
Patent Status:
DHHS Reference No. E-131-2000/0 --
PCT Patent Application No. PCT/US01/16058 filed 18 May 2001
Australian Patent Application No. 2001261743 filed 18 May 2001
Canadian Patent Application No. 2409298 filed 18 May 2001
European Patent Application No. 01935670.8-24 filed 18 May 2001
U.S. Patent Application No. 10/276,644 filed 10 March 2003
Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Portfolios: Cancer
Cancer -Therapeutics-Immunoconjugates-Mab Cancer -Therapeutics-Immunoconjugates-Other Cancer -Therapeutics-Biological Response Modifiers-Cytokines Cancer -Therapeutics
For Additional Information Please Contact: Jasbir (Jesse) S. Kindra J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5559
Email: kindraj@mail.nih.gov
Fax: (301) 402-0220
