Methods for High-Efficiency Single Genome Sequencing of HIV
Description of Invention:
The invention is directed to a method for efficiently obtaining single genome sequences (SGS) of HIV from a biological sample. The invention has the following advantages over the current commercial genotyping in use: 1) It might improve the sensitivity of diagnosis of drug resistant HIV in newly infected HIV patients; 2) It might provide a more affordable diagnostic tool for early detection of drug resistance since the invention is adaptable to an automated approach for the high-throughput processing of a large number of patient sample; 3) It might improve patient outcome since SGS has the ability to identify low level mutation and will permit a more comprehensive evaluation of resistance in patients and might potentially change the clinical approach to treating resistant virus. In summary, this invention might be a new important diagnostic tool for AIDS patients.
Inventors:
John Coffin (NCI) Mary Kearney (NCI) Frank Maldarelli (NCI) Sarah E. Palmer (NCI) et al.
Patent Status:
DHHS Reference No. E-022-2005/0-US-01 -- U.S. Provisional Application filed 25 Jan 2005
Relevant Publication:
Sarah Palmer et al., "Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-Experienced Patients are Missed by Standard Genotype Analysis," J. Clin. Microbiol. (Jan 2005) 43(1):406-413.
Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
For Additional Information Please Contact: Sally Hu PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5606
Email: hus@mail.nih.gov
Fax: (301) 402-0220
