Anti-HIV Peptide Secreting Bacteria: Therapeutics and Methods of Use
Description of Invention:
Available for licensing and commercial development are genetically engineered commensal bacteria compositions that secrete HIV infectivity interfering peptides with the aid of co-expressed translocation mediators such as HylB, HylD or tolC gene products. The bacteria can be, for example, Escherichia coli and are preferably those that colonize the gastrointestinal or genitourinary tracts. The secreted anti-HIV peptide can be a functional inhibitory fragment from the C-terminus of HIV, SHIV or SIV, or an inhibitory peptide derived from the N-terminus receptor-binding domain of SIV gp41, HIV-1 gp41, or HIV-2 gp41. The secreted anti-HIV peptide can also be a peptide from the allosteric domain of gp120, an extracellular loop of CCR5, an anti-CD4 immunoglobulin, a mimetic of CD4, an alpha-defensin or theta-defensin, a CD38 fragment homologous to the V3 loop of gp120, polphemusin II (a CXCR4 antagonist), a RANTES peptide that binds to CCR5 or an HIV surface binding peptide such as cyanovirin.
Inventors:
Dean Hamer (NCI)
Patent Status:
DHHS Reference No. E-233-2004/0 --
U.S. Provisional Application No. 60/604,051 filed 25 Aug 2004
DHHS Reference No. E-233-2004/1 --
U.S. Provisional Application No. 60/688,376 filed 08 Jun 2005
Portfolios: Infectious Diseases Gene Based Therapies
Gene Based Therapies -Therapeutics-Gene Therapy-Vectors-Non-viral vectors Gene Based Therapies -Therapeutics-Oligonucleotide Based Therapies-Delivery Mechanisms Gene Based Therapies -Therapeutics-Oligonucleotide Based Therapies-Other Gene Based Therapies -Therapeutics-Gene Therapy-Vectors Infectious Diseases -Therapeutics-Anti-Viral-AIDS (only) Gene Based Therapies -Therapeutics-Oligonucleotide Based Therapies Gene Based Therapies -Therapeutics-Gene Therapy Infectious Diseases -Therapeutics-Anti-Viral Gene Based Therapies -Therapeutics Infectious Diseases -Therapeutics
For Additional Information Please Contact: Michael Shmilovich J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-5019
Email: shmilovm@mail.nih.gov
Fax: (301) 402-0220
