Office Contact Info.
Phone: (631) 344-3604
Fax: (631) 344-2358
Mail address: Bldg. 490

Anat Biegon

Scientist


Telephone:  (631) 344-4882
e-mail:  biegon@bnl.gov

Research Interests

  • Brain response to traumatic, ischemic or inflammatory insults
  • Sex differences and gonadal hormone modulation of brain function in health and disease
  • Development and validation of radiopharmaceuticals for non invasive imaging of neurotransmitter and hormone markers in the brain
  • Traumatic bran injury is the leading cause of mortality and morbidity among young (18-24 year old) people in industrialized countries. It is also a major risk factor for developing Alzheimer's disease later in life. Brain ischemia (stroke, cardiac arrest, bypass surgery) and inflammation also increase the risk of developing dementia. For reasons that are not understood to date; Alzheimer's disease and inflammatory/autoimmune diseases such as multiple sclerosis are far more common (2-3 fold) in women than in men. Our recent and current studies focus on the 3-way interaction between inflammation, glutamate receptor activation and gonadal hormones in determining the outcome of traumatic, ischemic and inflammatory insults in animal models and human subjects. The techniques used include quantitative in vitro and ex vivo autoradiography, CT, structural MRI and functional MRI. To facilitate further translation of the current animal work to humans, we are developing radiopharmaceuticals for PET imaging of glutamate (NMDA) and estrogen receptors in the human brain.

 Education & Concurrent Positions

  • B.S. Chemistry, Tel Aviv University, 1973
  • M.S. Biochemistry, Tel Aviv University, 1975
  • Ph.D Neurobiology, Weizmann Institute of Science, Israel, 1980
  • Post Doctoral fellowship in Neuroendocrinology, Rockefeller Univ. NY, 1980-1982
  • Senior Scientist, Brookhaven National Laboratory, Upton, 2003-present

Selected Publications

    Biegon A., Gibbs A., Alvarado M., Ono M. and Taylor S.
    In vitro and In vivo characterization of [3H]CNS-5161-a use dependent ligand for the N-Methyl-d-Aspartate receptor in rat brain.
    Synapse, 61(8):577-86 (2007). PubMed

    Frumberg D.B., Fernando M.S., Lee D.E., Biegon A. and Schiffer W.K.
    Metabolic and behavioral deficits following a routine surgical procedure in rats.
    Brain Res., 1144:209-218 (2007). PubMed

    Yaka R., Biegon A., Grigoriadis N., Simeonidou C., Grigoriadis S., Alexandrovich A.G., Matzner H., Schumann J., Trembovler V., Tsenter J. and Shohami E.
    D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury.
    FASEB J, 21(9):2033-2041 (2007). PubMed

    Biegon A., Fry P.A., Paden C.M., Alexandrovich A., Tsenter J. and Shohami E.
    Dynamic changes in NMDA receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits.
    PNAS, 101(14):5117-5122 (2004). PubMed

    Pareto D., Alvarado M., Hanrahan S.M. and Biegon A.
    In vivo occupancy of female rat Brain estrogen receptors by17beta-estradiol and tamoxifen.
    NeuroImage, 23(3):1161-1167 (2004). PubMed

    Farin A., Deutsch R., Biegon A. and Marshall L.F.
    Gender Differences in Severe Head Injury: Women 50 and Younger More Susceptible to Brain Swelling.
    J. Neurosurg. 98:32-36 (2003). PubMed

    Grossman R., Shohami E., Alexandrovich A., Yatsiv I., Kloog A. and Biegon A.
    Increase in Peripheral Benzodiazepine Receptors and Loss of Glutamate NMDA receptors in a mouse model of closed head injury: A Quantitative auto- radiographic study.
    NeuroImage 20:1971- 1981(2003). PubMed

    Biegon A., Alvarado M., Budinger T.F., Grossman R., Hensley K., West M.S. Kotake Y., Ono M. and Floyd R.A.
    Region Selective Effects of Neuroinflammation and Antioxidant Treatment on Peripheral Benzodiazepine Receptors and NMDA Receptors in the Rat Brain.
    J. Neurochem. 82:1-11 (2002). PubMed

    Knoller N., Levi L. Israel Z., Razon N., Reichental E., Rappaport Z. and Biegon A.
    Dexanabinol (HU-211) in the treatment of severe closed head injury: A randomized placebo-controlled phase II clinical trial.
    Critical Care Medicine 30:548-554 (2002). PubMed

    Biegon A. and Kerman I.
    Autoradiographic Study of Pre- and Post-natal Distribution of Cannabinoid Receptors in Human Brain.
    Neuroimage, 14:1463-1468 (2001).
    PubMed

    Biegon A., Mathis C. and Jagust W.
    Autoradiography as a tool for PET/SPECT tracer selection and assessment . In: Quantifiaction of Brain function using PET; Myers, R., Cunningham, V.J., Bailey, D. L. and Jones, T.; Eds.
    Academic Press p.26-33 (1996).

    Biegon A. and Volkow N.D.
    Localization and characterization of drug binding sites in the human brain: Methodological considerations. In: Sites of drug action in the Human Brain; Biegon, A. and Volkow, N. Eds.
    CRC press, pp. 65-74 (1995)

    Biegon A. and Volkow ND. (Eds)
    Sites of Drug Action In the Human Brain.
    CRC Press, Boca Raton (1995).

    Biegon A.
    Serotonin, acetylcholine and beta-adrenoceptors. In: Receptors in the Human brain. Paxinos and Mendelsohn, eds.
    Academic Press, 149-167 (1991).

    Biegon A.
    Quantitative Autoradiography and Histochemistry of Neurochemicals in the Human Brain Postmortem. In: Brain Imaging: Techniques and Applications.
    Ellis Horwood Ltd. Chichister, UK pp. 130-143 (1989).

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Last Modified: May 12, 2008
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