| | Other Issues: previous | next | latest | archiveBook Reviews Review of "Evaluating Clinical Research – All that glitters is not gold" by Bengt D. Furberg and Curt D. Furberg Desmond Julian PMCID: PMC2409292 Review of: Interpreting and Reporting Clinical Trials – A guide to the CONSORT statement and the principles of randomised controlled trials by Anthony Keech, Val Gebski and Rhana Pike Stephen JW Evans PMCID: PMC2430542 Commentaries Competing risk and heterogeneity of treatment effect in clinical trials David M Kent, Alawi Alsheikh-Ali, and Rodney A Hayward PMCID: PMC2423182 Do we want more cancer patients on clinical trials If so, what are the barriers to greater accrual Andrew J Vickers PMCID: PMC2429895 Letter Economic evaluation alongside pragmatic randomised trials: developing a standard operating procedure for clinical trials units Rhiannon T Edwards, Barry Hounsome, Pat Linck, and Ian T Russell PMCID: PMC2615739 Methodology A concept for trial institutions focussing on randomised controlled trials in surgery Nuh N Rahbari, Markus K Diener, Lars Fischer, Moritz N Wente, Peter Kienle, Markus W Büchler, and Christoph M Seiler PMCID: PMC2259294 Seminars may increase recruitment to randomised controlled trials: lessons learned from WISDOM Bronwen J Paine, Nigel P Stocks, and Alastair H MacLennan PMCID: PMC2249567 From multidimensional neuropsychological outcomes to a cognitive complication rate: The International Subarachnoid Aneurysm Trial Richard B Scott, Fiona Eccles, Andrew Lloyd, and Katherine Carpenter PMCID: PMC2322951 Initial experience with a group presentation of study results to research participants Andrew L Avins, Stephen Bent, Amy Padula, Suzanne Staccone, Evelyn Badua, and Harley Goldberg PMCID: PMC2322950 Reporting of noninferiority and equivalence randomized trials for major prostaglandins: A systematic survey of the ophthalmology literature Oghenowede Eyawo, Chia-Wen Lee, Beth Rachlis, and Edward J Mills PMCID: PMC2621118 Research Workflow to improve patient recruitment for clinical trials within hospital information systems – a case-study Martin Dugas, Matthias Lange, Wolfgang E Berdel, and Carsten Müller-Tidow PMCID: PMC2253503 A study to assess changes in myocardial perfusion after treatment with spinal cord stimulation and percutaneous myocardial laser revascularisation; data from a randomised trial Sadia N Khan, Duncan C McNab, Linda D Sharples, Carol J Freeman, Ian Hardy, David L Stone, and Peter M Schofield PMCID: PMC2266700 Echocardiographic predictors of severe heart failure symptoms in hypertrophic cardiomyopathy patients with sinus rhythm Fatih Bayrak, Gokhan Kahveci, Muzaffer Degertekin, and Bulent Mutlu PMCID: PMC2292134 What constitutes a "clinical trial"?: A survey of oncology professionals James R Wright, Brenda Kowaleski, and Jonathan Sussman PMCID: PMC2267771 Endorsement of the CONSORT Statement by high impact factor medical journals: a survey of journal editors and journal 'Instructions to Authors' Sally Hopewell, Douglas G Altman, David Moher, and Kenneth F Schulz PMCID: PMC2359733 An assessment of the quality of randomised controlled trials conducted in China Dalu Zhang, Peng Yin, Nick Freemantle, Rachel Jordan, Nanshan Zhong, and KK Cheng PMCID: PMC2373774 Pearls and perils of an implantable defibrillator trial using a common control: implications for the design of future studies Peter J Kudenchuk and Alfred P Hallstrom PMCID: PMC2397377 Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations Jaime Algorta, Maria Angeles Pena, Silvia Francisco, Zurine Abajo, and Emilio Sanz PMCID: PMC2453102 Inefficacy of different strategies to improve guideline awareness – 5-year follow-up of the hypertension evaluation project (HEP) Jens Hagemeister, Christian A Schneider, Holger Diedrichs, Diana Mebus, Holger Pfaff, Gernot Wassmer, and Hans W Höpp PMCID: PMC2443109 Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: The SPiRiT trial M T Dyer, KA Goldsmith, SN Khan, LD Sharples, C Freeman, I Hardy, MJ Buxton, and PM Schofield PMCID: PMC2481243 Informed consent for clinical trials in acute coronary syndromes and stroke following the European Clinical Trials Directive: investigators' experiences and attitudes Piotr Iwanowski, Andrzej Budaj, Anna Członkowska, Wojciech Wąsek, Beata Kozłowska-Boszko, Urszula Olędzka, and Wojciech Masełbas PMCID: PMC2517587 Approaches to interim analysis of cancer randomised clinical trials with time to event endpoints: A survey from the Italian National Monitoring Centre for Clinical Trials Irene Floriani, Nicole Rotmensz, Elena Albertazzi, Valter Torri, Marisa De Rosa, Carlo Tomino, and Fillipo de Braud PMCID: PMC2533282 Meta-analysis of trials comparing anastrozole and tamoxifen for adjuvant treatment of postmenopausal women with early breast cancer Adnan Aydiner and Faruk Tas PMCID: PMC2503952 The VEPRO trial: A cross-over randomised controlled trial comparing 2 progressive lenses for patients with presbyopia Isabelle Boutron, Caroline Touizer, Isabelle Pitrou, Carine Roy, and Philippe Ravaud PMCID: PMC2556995 Study Protocol The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) study: Multicenter randomized, double-blind, controlled trial of laparoscopic (LC) versus open (LTC) surgery for acute cholecystitis (AC) in adults Fausto Catena, Luca Ansaloni, Salomone Di Saverio, Filippo Gazzotti, Stefano Gagliardi, Federico Coccolini, Luigi D'Alessandro, Giorgio Ercolani, Carlo Talarico, Uberto A Bassi, Leonardo Leone, Filippo Calzolari, and Antonio D Pinna PMCID: PMC2244597 Improving the outcomes of primary care attenders with common mental disorders in developing countries: a cluster randomized controlled trial of a collaborative stepped care intervention in Goa, India Vikram H Patel, Betty R Kirkwood, Sulochana Pednekar, Ricardo Araya, Michael King, Daniel Chisholm, Gregory Simon, and Helen Weiss PMCID: PMC2265673 Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial Rathie Rajendram, Richard WJ Lee, Mike J Potts, Geoff E Rose, Rajni Jain, Jane M Olver, Fion Bremner, Steven Hurel, Anne Cook, Rao Gattamaneni, Marjorie Tomlinson, Nicholas Plowman, Catey Bunce, Sandra P Hollinghurst, Laura Kingston, Sue Jackson, Andrew D Dick, Nichola Rumsey, Olivia C Morris, Colin M Dayan, and Jimmy M Uddin PMCID: PMC2275219 Cluster-randomised controlled trial of community mobilisation in Mumbai slums to improve care during pregnancy, delivery, postpartum and for the newborn Neena Shah More, Ujwala Bapat, Sushmita Das, Sarita Patil, Maya Porel, Leena Vaidya, Bhaveshree Koriya, Sarah Barnett, Anthony Costello, Armida Fernandez, and David Osrin PMCID: PMC2259295 Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study) David C Crossman, Allison C Morton, Julian P Gunn, John P Greenwood, Alistair S Hall, Keith AA Fox, Andrew J Lucking, Marcus D Flather, Belinda Lees, and Claire E Foley PMCID: PMC2289802 Efficacy of acupuncture for chronic low back pain: protocol for a randomized controlled trial Daniel C Cherkin, Karen J Sherman, Charissa J Hogeboom, Janet H Erro, William E Barlow, Richard A Deyo, and Andrew L Avins PMCID: PMC2276474 Randomised controlled trial of thermostatic mixer valves in reducing bath hot tap water temperature in families with young children in social housing: A protocol Denise Kendrick, Jane Stewart, Carol Coupland, Michael Hayes, Nick Hopkins, Debbie McCabe, Robert Murphy, George O'Donnell, Ceri Phillips, David Radford, Jackie Ryan, Sherie Smith, Lindsay Groom, and Elizabeth Towner PMCID: PMC2322949 Community based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or transient ischaemic attack recently discharged from hospital Sally Kerry, Hugh Markus, Teck Khong, Reena Doshi, Rachel Conroy, and Pippa Oakeshott PMCID: PMC2294111 TIPIT: A randomised controlled trial of thyroxine in preterm infants under 28 weeks' gestation Sze M Ng, Mark A Turner, Carrol Gamble, Mohammed Didi, Suresh Victor, and Alan M Weindling PMCID: PMC2335090 Design of the Pacemaker REmote Follow-up Evaluation and Review (PREFER) trial to assess the clinical value of the remote pacemaker interrogation in the management of pacemaker patients Jane Chen, Bruce L Wilkoff, Wassim Choucair, Todd J Cohen, George H Crossley, W Ben Johnson, Luc R Mongeon, Gerald A Serwer, and Lou Sherfesee PMCID: PMC2311273 A randomized double-blind placebo-controlled trial to investigate the effects of nasal calcitonin on bone microarchitecture measured by high-resolution peripheral quantitative computerized tomography in postmenopausal women — Study protocol Laura Richert, Brigitte Uebelhart, Marc Engelhardt, Moise Azria, and René Rizzoli PMCID: PMC2373283 Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol Lara R Fairall, Max O Bachmann, Merrick F Zwarenstein, Carl J Lombard, Kerry Uebel, Cloete van Vuuren, Dewald Steyn, Andrew Boulle, and Eric D Bateman PMCID: PMC2377234 Effectiveness of computer-tailored Smoking Cessation Advice in Primary Care (ESCAPE): a Randomised Trial Hazel Gilbert, Irwin Nazareth, Stephen Sutton, Richard Morris, and Christine Godfrey PMCID: PMC2409293 The potential of Virtual Reality as anxiety management tool: a randomized controlled study in a sample of patients affected by Generalized Anxiety Disorder Alessandra Gorini and Giuseppe Riva PMCID: PMC2412841 GALA: an international multicentre randomised trial comparing general anaesthesia versus local anaesthesia for carotid surgery Michael J Gough, Andrew Bodenham, Michael Horrocks, Bridget Colam, Steff C Lewis, Peter M Rothwell, Adrian P Banning, David Torgerson, Moira Gough, Demosthenes Dellagrammaticas, Anne Leigh-Brown, Christos Liapis, and Charles Warlow PMCID: PMC2413207 GENetic and clinical Predictors Of treatment response in Depression: the GenPod randomised trial protocol Laura Thomas, Jean Mulligan, Victoria Mason, Debbie Tallon, Nicola Wiles, Philip Cowen, David Nutt, Michael O'Donovan, Deborah Sharp, Tim Peters, and Glyn Lewis PMCID: PMC2426669 Efficacy of tibolone and raloxifene for the maintenance of skeletal muscle strength, bone mineral density, balance, body composition, cognitive function, mood/depression, anxiety and quality of life/well-being in late postmenopausal women ≥ 70 years: Study design of a randomized, double-blind, double-dummy, placebo-controlled, single-center trial Didy E Jacobsen, Monique M Samson, Yvonne T van der Schouw, Diederick E Grobbee, and Harald JJ Verhaar PMCID: PMC2427014 Study protocol for a three-armed randomized controlled trial to assess whether house screening can reduce exposure to malaria vectors and reduce malaria transmission in The Gambia Matthew J Kirby, Paul J Milligan, David J Conway, and Steve W Lindsay PMCID: PMC2427015 The SU.FOL.OM3 Study: a secondary prevention trial testing the impact of supplementation with folate and B-vitamins and/or Omega-3 PUFA on fatal and non fatal cardiovascular events, design, methods and participants characteristics Pilar Galan, Serge Briancon, Jacque Blacher, Sébastien Czernichow, and Serge Hercberg PMCID: PMC2464576 Automated external cardioversion defibrillation monitoring in cardiac arrest: a randomized trial Bakhtiar Ali, Heather Bloom, Emir Veledar, Dorothy House, Robert Norvel, Samuel C Dudley, and A Maziar Zafari PMCID: PMC2440367 The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke Peter Sandercock, Richard Lindley, Joanna Wardlaw, Martin Dennis, Steff Lewis, Graham Venables, Adam Kobayashi, Anna Czlonkowska, Eivind Berge, Karsten Bruins Slot, Veronica Murray, Andre Peeters, Graeme Hankey, Karl Matz, Michael Brainin, Stefano Ricci, Maria Grazia Celani, Enrico Righetti, Teresa Cantisani, Gord Gubitz, Steve Phillips, Antonio Arauz, Kameshwar Prasad, Manuel Correia, Phillippe Lyrer, and the IST-3 collaborative group PMCID: PMC2442584 Effectiveness of the Austrian disease-management-programme for type 2 diabetes: study protocol of a cluster-randomized controlled trial Andreas C Sönnichsen, Andreas Rinnerberger, Maria G Url, Henrike Winkler, Peter Kowatsch, Gert Klima, Bernhard Fürthauer, and Raimund Weitgasser PMCID: PMC2443108 Multicenter double blind trial of autologous bone marrow mononuclear cell transplantation through intracoronary injection post acute myocardium infarction – MiHeart/AMI study Hans FR Dohmann, Suzana A Silva, André LS Sousa, Alcione MS Braga, Rodrigo VC Branco, Andréa F Haddad, Mônica A Oliveira, Rodrigo C Moreira, Fabio AA Tuche, Cíntia M Peixoto, Bernardo R Tura, Radovan Borojevic, Jorge P Ribeiro, José C Nicolau, Antonio C Nóbrega, and Antonio CC Carvalho PMCID: PMC2486263 Design paper: The CapOpus trial: A randomized, parallel-group, observer-blinded clinical trial of specialized addiction treatment versus treatment as usual for young patients with cannabis abuse and psychosis Carsten Hjorthøj, Allan Fohlmann, Anne-Mette Larsen, Mette TR Madsen, Lone Vesterager, Christian Gluud, Mikkel C Arendt, and Merete Nordentoft PMCID: PMC2475529 The TEAM trial: Safety and efficacy of endovascular treatment of unruptured intracranial aneurysms in the prevention of aneurysmal hemorrhages: A randomized comparison with indefinite deferral of treatment in 2002 patients followed for 10 years Jean Raymond, Andrew J Molyneux, Allan J Fox, S Claiborne Johnston, Jean-Paul Collet, Isabelle Rouleau, and the TEAM collaborative group PMCID: PMC2526062 Rationale, design and methodology for a Prospective Randomized Study of graft patency in Off-pump and On-pump MultI-Vessel coronary artery bypasS Surgery (PROMISS) using multidetector computed tomography Miguel Sousa Uva, Fernando Matias, Sara Cavaco, and Manuel Pedro Magalhães PMCID: PMC2492837 Bright light in elderly subjects with nonseasonal major depressive disorder: a double blind randomised clinical trial using early morning bright blue light comparing dim red light treatment Ritsaert Lieverse, Marjan MA Nielen, Dick J Veltman, Bernard MJ Uitdehaag, Eus JW van Someren, Jan H Smit, and Witte JG Hoogendijk PMCID: PMC2553185 Non-invasive cardiac assessment in high risk patients (The GROUND study): rationale, objectives and design of a multi-center randomized controlled clinical trial Alexander M de Vos, Annemarieke Rutten, Hester J van de Zaag-Loonen, Michiel L Bots, Riksta Dikkers, Robert A Buiskool, Willem P Mali, Daniel D Lubbers, Arend Mosterd, Mathias Prokop, Benno J Rensing, Maarten J Cramer, H Wouter van Es, Frans L Moll, Eric D van de Pavoordt, Pieter A Doevendans, Birgitta K Velthuis, Albert J Mackaay, Felix Zijlstra, and Matthijs Oudkerk PMCID: PMC2519056 A pragmatic cluster randomised controlled trial to evaluate the safety, clinical effectiveness, cost effectiveness and satisfaction with point of care testing in a general practice setting – rationale, design and baseline characteristics Caroline Laurence, Angela Gialamas, Lisa Yelland, Tanya Bubner, Philip Ryan, Kristyn Willson, Briony Glastonbury, Janice Gill, Mark Shephard, Justin Beilby, and members of the PoCT Trial Management Committee PMCID: PMC2519057 A randomized comparative study of patients undergoing myocardial revascularization with or without cardiopulmonary bypass surgery: The MASS III Trial Whady Hueb, Neuza HM Lopes, Bernard J Gersh, Cláudio C Castro, Felipe S Paulitsch, Sergio A Oliveira, Luis A Dallan, Alexandre C Hueb, Noedir A Stolf, and José AF Ramires PMCID: PMC2553048 Magnet therapy for the relief of pain and inflammation in rheumatoid arthritis (CAMBRA): A randomised placebo-controlled crossover trial Stewart J Richmond PMCID: PMC2556642 European trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): A randomised control trial Colin A Hutchison, Mark Cook, Nils Heyne, Katja Weisel, Lucinda Billingham, Arthur Bradwell, and Paul Cockwell PMCID: PMC2564897 A randomised, double-masked phase III/IV study of the efficacy and safety of Avastin® (Bevacizumab) intravitreal injections compared to standard therapy in subjects with choroidal neovascularisation secondary to age-related macular degeneration: clinical trial design Praveen J Patel, Catey Bunce, Adnan Tufail, and the ABC Trial Investigators PMCID: PMC2576049 Randomized controlled trial to treat migraine with acupuncture: design and protocol Ying Li, Fanrong Liang, Shuguang Yu, Xuguang Liu, Yong Tang, Xuguang Yang, Xiaoping Tian, Jie Yan, Guojie Sun, Xiaorong Chang, Hui Zheng, Hongxing Zhang, and Tingting Ma PMCID: PMC2577624 Perioperative oxygen fraction – effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial Christian S Meyhoff, Jørn Wetterslev, Lars N Jorgensen, Steen W Henneberg, Inger Simonsen, Therese Pulawska, Line R Walker, Nina Skovgaard, Kim Heltø, Peter Gocht-Jensen, Palle S Carlsson, Henrik Rask, Sharaf Karim, Charlotte G Carlsen, Frank S Jensen, Lars S Rasmussen, and the PROXI Trial Group PMCID: PMC2600782 Study design and methods of the BoTULS trial: a randomised controlled trial to evaluate the clinical effect and cost effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A Helen Rodgers, Lisa Shaw, Christopher Price, Frederike van Wijck, Michael Barnes, Laura Graham, Gary Ford, Phil Shackley, Nick Steen, and BoTULS investigators PMCID: PMC2611962 Protocol of an expertise based randomized trial comparing surgical Venae Sectio versus radiological Puncture of Vena Subclavia for insertion of Totally Implantable Access Port in oncological patients Philip Knebel, Lars Fischer, Eva Cremonese, Ruben Lopez-Benitez, Ulrike Stampfl, Boris Radeleff, Hans-Ulrich Kauczor, Markus W Büchler, and Christoph M Seiler PMCID: PMC2579421 Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial: FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study) Noemi Lois, Jennifer Burr, John Norrie, Luke Vale, Jonathan Cook, Alison McDonald, and the Full-thickness macular hole and Internal Limiting Membrane peeling Study (FILMS) Group PMCID: PMC2607251 Community-based randomised controlled trial evaluating falls and osteoporosis risk management strategies PM Ciaschini, SE Straus, LR Dolovich, RA Goeree, KM Leung, CR Woods, GM Zimmerman, SR Majumdar, S Spadafora, LA Fera, and HN Lee PMCID: PMC2612651 ZAMSTAR, The Zambia South Africa TB and HIV Reduction study: Design of a 2 × 2 factorial community randomized trial Helen M Ayles, Charalambos Sismanidis, Nulda Beyers, Richard J Hayes, and Peter Godfrey-Faussett PMCID: PMC2585552 VAST: Vertebral Artery Stenting Trial. Protocol for a randomised safety and feasibility trial A Compter, HB van der Worp, WJ Schonewille, JA Vos, A Algra, TH Lo, WPThM Mali, FL Moll, and LJ Kappelle PMCID: PMC2611963 Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: Rationale and design of the Sonolysis study Jeroen Slikkerveer, Pieter A Dijkmans, Gertjan T Sieswerda, Pieter AFM Doevendans, Arie PJ van Dijk, Freek WA Verheugt, Thomas R Porter, and Otto Kamp PMCID: PMC2614934 Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial Pippa Oakeshott, Sally Kerry, Helen Atherton, Adamma Aghaizu, Sima Hay, David Taylor-Robinson, Ian Simms, and Phillip Hay PMCID: PMC2614935 |
