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Volume 4;  2008
Editorials
Hit a new high
Min Zhuo and Jianguo Gu
Mol Pain. 2008; 4: 4. Published online 2008 January 21. doi: 10.1186/1744-8069-4-4.
PMCID: PMC2245916
Z factor: a new index for measuring academic research output
Min Zhuo
Mol Pain. 2008; 4: 53. Published online 2008 November 9. doi: 10.1186/1744-8069-4-53.
PMCID: PMC2603001
Methodology
A computational model for sex-specific genetic architecture of complex traits in humans: Implications for mapping pain sensitivity
Chenguang Wang, Yun Cheng, Tian Liu, Qin Li, Roger B Fillingim, Margaret R Wallace, Roland Staud, Lee Kaplan, and Rongling Wu
Mol Pain. 2008; 4: 13. Published online 2008 April 16. doi: 10.1186/1744-8069-4-13.
PMCID: PMC2422840
Research
Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia
John K Neubert, Andrew J Mannes, Laszlo J Karai, Alan C Jenkins, Lanel Zawatski, Mones Abu-Asab, and Michael J Iadarola
Mol Pain. 2008; 4: 3. Published online 2008 January 16. doi: 10.1186/1744-8069-4-3.
PMCID: PMC2242785
Expression of AMPA receptor subunits at synapses in laminae I–III of the rodent spinal dorsal horn
Erika Polgár, Masahiko Watanabe, Bettina Hartmann, Seth GN Grant, and Andrew J Todd
Mol Pain. 2008; 4: 5. Published online 2008 January 23. doi: 10.1186/1744-8069-4-5.
PMCID: PMC2248168
Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision
DeYong Liang, Xiaoyou Shi, Yanli Qiao, Martin S Angst, David C Yeomans, and J David Clark
Mol Pain. 2008; 4: 7. Published online 2008 February 22. doi: 10.1186/1744-8069-4-7.
PMCID: PMC2279109
Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model
Hong Yang, Terry A McNearney, Rong Chu, Ying Lu, Yong Ren, David C Yeomans, Steven P Wilson, and Karin N Westlund
Mol Pain. 2008; 4: 8. Published online 2008 February 28. doi: 10.1186/1744-8069-4-8.
PMCID: PMC2292157
Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity
Reddy M Pabbidi, Shuang-Quan Yu, Siying Peng, Romesh Khardori, Mary E Pauza, and Louis S Premkumar
Mol Pain. 2008; 4: 9. Published online 2008 March 1. doi: 10.1186/1744-8069-4-9.
PMCID: PMC2275252
Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: Implications for chemical-induced peripheral sensory neuropathies
Juan M Jimenez-Andrade, Monica B Herrera, Joseph R Ghilardi, Marina Vardanyan, Ohannes K Melemedjian, and Patrick W Mantyh
Mol Pain. 2008; 4: 10. Published online 2008 March 19. doi: 10.1186/1744-8069-4-10.
PMCID: PMC2289805
Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
Fuxing Zhang, Kujumon I Vadakkan, Susan S Kim, Long-Jun Wu, Yuze Shang, and Min Zhuo
Mol Pain. 2008; 4: 15. Published online 2008 April 18. doi: 10.1186/1744-8069-4-15.
PMCID: PMC2374773
Nav1.7 expression is increased in painful human dental pulp
Songjiang Luo, Griffin M Perry, S Rock Levinson, and Michael A Henry
Mol Pain. 2008; 4: 16. Published online 2008 April 21. doi: 10.1186/1744-8069-4-16.
PMCID: PMC2377237
Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia
Xiu-Yu Cui, Yi Dai, Sheng-Lan Wang, Hiroki Yamanaka, Kimiko Kobayashi, Koichi Obata, Jun Chen, and Koichi Noguchi
Mol Pain. 2008; 4: 17. Published online 2008 April 30. doi: 10.1186/1744-8069-4-17.
PMCID: PMC2391153
Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
Ruth Drdla and Jürgen Sandkühler
Mol Pain. 2008; 4: 18. Published online 2008 May 28. doi: 10.1186/1744-8069-4-18.
PMCID: PMC2424039
Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition
Jean-Didier Breton, Pierre Veinante, Sandra Uhl-Bronner, Angela Maria Vergnano, Marie José Freund-Mercier, Rémy Schlichter, and Pierrick Poisbeau
Mol Pain. 2008; 4: 19. Published online 2008 May 29. doi: 10.1186/1744-8069-4-19.
PMCID: PMC2430948
Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury
Zhi-Jiang Huang and Xue-Jun Song
Mol Pain. 2008; 4: 20. Published online 2008 May 30. doi: 10.1186/1744-8069-4-20.
PMCID: PMC2427019
TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
Hong Xing, Jennifer X Ling, Meng Chen, Richard D Johnson, Makoto Tominaga, Cong-Yi Wang, and Jianguo Gu
Mol Pain. 2008; 4: 22. Published online 2008 June 5. doi: 10.1186/1744-8069-4-22.
PMCID: PMC2430548
Involvement of P311 in the affective, but not in the sensory component of pain
Yan-Gang Sun, Yong-Jing Gao, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A Taylor, and Zhou-Feng Chen
Mol Pain. 2008; 4: 23. Published online 2008 June 12. doi: 10.1186/1744-8069-4-23.
PMCID: PMC2459156
Pharmacological switch in Aβ-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury
Misaki Matsumoto, Weijiao Xie, Lin Ma, and Hiroshi Ueda
Mol Pain. 2008; 4: 25. Published online 2008 July 11. doi: 10.1186/1744-8069-4-25.
PMCID: PMC2488330
PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior
Yu Fu, Jeong Han, Titilope Ishola, Michelle Scerbo, Hita Adwanikar, Cara Ramsey, and Volker Neugebauer
Mol Pain. 2008; 4: 26. Published online 2008 July 16. doi: 10.1186/1744-8069-4-26.
PMCID: PMC2490682
Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats
Chang-Qi Li, Jun-Mei Xu, Dan Liu, Jian-Yi Zhang, and Ru-Ping Dai
Mol Pain. 2008; 4: 27. Published online 2008 July 17. doi: 10.1186/1744-8069-4-27.
PMCID: PMC2492846
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
Lillian Cruz-Orengo, Ajay Dhaka, Robert J Heuermann, Timothy J Young, Michael C Montana, Eric J Cavanaugh, Donghee Kim, and Gina M Story
Mol Pain. 2008; 4: 30. Published online 2008 July 31. doi: 10.1186/1744-8069-4-30.
PMCID: PMC2515828
Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain
Tatsuo Yamamoto, Alan Kozikowski, Jia Zhou, and Joseph H Neale
Mol Pain. 2008; 4: 31. Published online 2008 August 1. doi: 10.1186/1744-8069-4-31.
PMCID: PMC2517065
Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons
Katharina Funk, Anne Woitecki, Christina Franjic-Würtz, Thomas Gensch, Frank Möhrlen, and Stephan Frings
Mol Pain. 2008; 4: 32. Published online 2008 August 12. doi: 10.1186/1744-8069-4-32.
PMCID: PMC2526990
Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves
Hong-Lei Huang, Cruz-Miguel Cendan, Carolina Roza, Kenji Okuse, Rainer Cramer, John F Timms, and John N Wood
Mol Pain. 2008; 4: 33. Published online 2008 August 12. doi: 10.1186/1744-8069-4-33.
PMCID: PMC2525634
Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats
Jin-Yan Wang, Han-Ti Zhang, Jing-Yu Chang, Donald J Woodward, Luiz A Baccalá, and Fei Luo
Mol Pain. 2008; 4: 34. Published online 2008 August 26. doi: 10.1186/1744-8069-4-34.
PMCID: PMC2531182
Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn
Sandrine M Géranton, Vincenza Fratto, Keri K Tochiki, and Stephen P Hunt
Mol Pain. 2008; 4: 35. Published online 2008 September 15. doi: 10.1186/1744-8069-4-35.
PMCID: PMC2553762
The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury
Samuel W Cramer, Christopher Baggott, John Cain, Jessica Tilghman, Bradley Allcock, Gurwattan Miranpuri, Sharad Rajpal, Dandan Sun, and Daniel Resnick
Mol Pain. 2008; 4: 36. Published online 2008 September 17. doi: 10.1186/1744-8069-4-36.
PMCID: PMC2561007
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable
Sulayman D Dib-Hajj, Mark Estacion, Brian W Jarecki, Lynda Tyrrell, Tanya Z Fischer, Mark Lawden, Theodore R Cummins, and Stephen G Waxman
Mol Pain. 2008; 4: 37. Published online 2008 September 19. doi: 10.1186/1744-8069-4-37.
PMCID: PMC2556659
The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
Jun-Gang Wang, Judith A Strong, Wenrui Xie, Rui-Hua Yang, Dennis E Coyle, Dayna M Wick, Ericka D Dorsey, and Jun-Ming Zhang
Mol Pain. 2008; 4: 38. Published online 2008 September 24. doi: 10.1186/1744-8069-4-38.
PMCID: PMC2562993
Effect of excitatory and inhibitory agents and a glial inhibitor on optically-recorded primary-afferent excitation
Hiroshi Ikeda, Takaki Kiritoshi, and Kazuyuki Murase
Mol Pain. 2008; 4: 39. Published online 2008 September 26. doi: 10.1186/1744-8069-4-39.
PMCID: PMC2565671
Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
Long-Jun Wu, Hendrik W Steenland, Susan S Kim, Carolina Isiegas, Ted Abel, Bong-Kiun Kaang, and Min Zhuo
Mol Pain. 2008; 4: 40. Published online 2008 September 29. doi: 10.1186/1744-8069-4-40.
PMCID: PMC2570662
Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice
Tsung-Chieh Chen, Ying-Ying Cheng, Wei-Zen Sun, and Bai-Chuang Shyu
Mol Pain. 2008; 4: 41. Published online 2008 September 30. doi: 10.1186/1744-8069-4-41.
PMCID: PMC2569012
Direct activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)
Dong Ho Woo, Sung Jun Jung, Mei Hong Zhu, Chul-Kyu Park, Yong Ho Kim, Seog Bae Oh, and C Justin Lee
Mol Pain. 2008; 4: 42. Published online 2008 October 1. doi: 10.1186/1744-8069-4-42.
PMCID: PMC2576176
Characterization of mouse orofacial pain and the effects of lesioning TRPV1-expressing neurons on operant behavior
John K Neubert, Christopher King, Wendi Malphurs, Fong Wong, James P Weaver, Alan C Jenkins, Heather L Rossi, and Robert M Caudle
Mol Pain. 2008; 4: 43. Published online 2008 October 1. doi: 10.1186/1744-8069-4-43.
PMCID: PMC2584042
Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons
Chi-Kun Tong, Edward J Kaftan, and Amy B MacDermott
Mol Pain. 2008; 4: 44. Published online 2008 October 10. doi: 10.1186/1744-8069-4-44.
PMCID: PMC2572590
Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein
Wen-Jinn Liaw, Xu-Guang Zhu, Myron Yaster, Roger A Johns, Estelle B Gauda, and Yuan-Xiang Tao
Mol Pain. 2008; 4: 45. Published online 2008 October 14. doi: 10.1186/1744-8069-4-45.
PMCID: PMC2576175
A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis
Marwan N Baliki, Paul Y Geha, Rami Jabakhanji, Norm Harden, Thomas J Schnitzer, and A Vania Apkarian
Mol Pain. 2008; 4: 47. Published online 2008 October 25. doi: 10.1186/1744-8069-4-47.
PMCID: PMC2584040
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
Samer R Eid, Eric D Crown, Eric L Moore, Hongyu A Liang, Kar-Chan Choong, Shelley Dima, Darrell A Henze, Stefanie A Kane, and Mark O Urban
Mol Pain. 2008; 4: 48. Published online 2008 October 27. doi: 10.1186/1744-8069-4-48.
PMCID: PMC2584039
Cutaneous tactile allodynia associated with microvascular dysfunction in muscle
Andre Laferrière, Magali Millecamps, Dimitris N Xanthos, Wen Hua Xiao, Chiang Siau, Marissa de Mos, Christelle Sachot, J Vaigunda Ragavendran, Frank JPM Huygen, Gary J Bennett, and Terence J Coderre
Mol Pain. 2008; 4: 49. Published online 2008 October 28. doi: 10.1186/1744-8069-4-49.
PMCID: PMC2584041
Quantitative Real-Time PCR detection of TRPV1–4 gene expression in human leukocytes from healthy and hyposensitive subjects
Giacomo Spinsanti, Raffaella Zannolli, Cristina Panti, Ilaria Ceccarelli, Letizia Marsili, Valeria Bachiocco, Francesco Frati, and Anna Maria Aloisi
Mol Pain. 2008; 4: 51. Published online 2008 November 4. doi: 10.1186/1744-8069-4-51.
PMCID: PMC2588574
Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey
Hyo-Jin Jeong, David Chenu, Emma E Johnson, Mark Connor, and Christopher W Vaughan
Mol Pain. 2008; 4: 54. Published online 2008 November 11. doi: 10.1186/1744-8069-4-54.
PMCID: PMC2588575
FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network
Wei Qin, Jie Tian, Lijun Bai, Xiaohong Pan, Lin Yang, Peng Chen, Jianping Dai, Lin Ai, Baixiao Zhao, Qiyong Gong, Wei Wang, Karen M von Deneen, and Yijun Liu
Mol Pain. 2008; 4: 55. Published online 2008 November 13. doi: 10.1186/1744-8069-4-55.
PMCID: PMC2596101
Single dose of morphine produced a prolonged effect on dopamine neuron activities
Die Zhang, Hai Zhang, Guo-zhang Jin, Kehong Zhang, and Xuechu Zhen
Mol Pain. 2008; 4: 57. Published online 2008 November 17. doi: 10.1186/1744-8069-4-57.
PMCID: PMC2603002
Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice
Yuan Han, Xue-Song Song, Wen-Tao Liu, Mark Henkemeyer, and Xue-Jun Song
Mol Pain. 2008; 4: 60. Published online 2008 November 21. doi: 10.1186/1744-8069-4-60.
PMCID: PMC2605438
Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury
Andrew Moss, Rachel Ingram, Stephanie Koch, Andria Theodorou, Lucie Low, Mark Baccei, Gareth J Hathway, Michael Costigan, Stephen R Salton, and Maria Fitzgerald
Mol Pain. 2008; 4: 62. Published online 2008 December 10. doi: 10.1186/1744-8069-4-62.
PMCID: PMC2614976
Long-term actions of interleukin-1β on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization
Sabrina L Gustafson-Vickers, Van B Lu, Aaron Y Lai, Kathryn G Todd, Klaus Ballanyi, and Peter A Smith
Mol Pain. 2008; 4: 63. Published online 2008 December 17. doi: 10.1186/1744-8069-4-63.
PMCID: PMC2625335
Reviews
Peripheral mechanisms of neuropathic pain – involvement of lysophosphatidic acid receptor-mediated demyelination
Hiroshi Ueda
Mol Pain. 2008; 4: 11. Published online 2008 April 1. doi: 10.1186/1744-8069-4-11.
PMCID: PMC2365930
Molecular and cellular limits to somatosensory specificity
Carlos Belmonte and Félix Viana
Mol Pain. 2008; 4: 14. Published online 2008 April 18. doi: 10.1186/1744-8069-4-14.
PMCID: PMC2386863
Histamine-induced itch and its relationship with pain
Won-Sik Shim and Uhtaek Oh
Mol Pain. 2008; 4: 29. Published online 2008 July 31. doi: 10.1186/1744-8069-4-29.
PMCID: PMC2519061
Effects of general anesthetics on visceral pain transmission in the spinal cord
Yun Wang, Jing Wu, Qing Lin, HJ Nauta, Yun Yue, and Li Fang
Mol Pain. 2008; 4: 50. Published online 2008 October 30. doi: 10.1186/1744-8069-4-50.
PMCID: PMC2584043
Short Reports
Mutation I136V alters electrophysiological properties of the NaV1.7 channel in a family with onset of erythromelalgia in the second decade
Xiaoyang Cheng, Sulayman D Dib-Hajj, Lynda Tyrrell, and Stephen G Waxman
Mol Pain. 2008; 4: 1. Published online 2008 January 2. doi: 10.1186/1744-8069-4-1.
PMCID: PMC2262064
The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
Peter J Cox, Tom Pitcher, Steven A Trim, Christine H Bell, Wenning Qin, and Ross A Kinloch
Mol Pain. 2008; 4: 2. Published online 2008 January 15. doi: 10.1186/1744-8069-4-2.
PMCID: PMC2242784
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
Makoto Inoue, Lin Ma, Junken Aoki, Jerold Chun, and Hiroshi Ueda
Mol Pain. 2008; 4: 6. Published online 2008 February 8. doi: 10.1186/1744-8069-4-6.
PMCID: PMC2277392
Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling
Yan Xiao, Judith A Richter, and Joyce H Hurley
Mol Pain. 2008; 4: 12. Published online 2008 April 16. doi: 10.1186/1744-8069-4-12.
PMCID: PMC2359740
Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia
Mark E Samuels, Rene HM te Morsche, Mary E Lynch, and Joost PH Drenth
Mol Pain. 2008; 4: 21. Published online 2008 June 2. doi: 10.1186/1744-8069-4-21.
PMCID: PMC2430949
Hemispheric lateralization of a molecular signal for pain modulation in the amygdala
Yarimar Carrasquillo and Robert W Gereau IV
Mol Pain. 2008; 4: 24. Published online 2008 June 23. doi: 10.1186/1744-8069-4-24.
PMCID: PMC2443116
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain
Feng Wei and Min Zhuo
Mol Pain. 2008; 4: 28. Published online 2008 July 23. doi: 10.1186/1744-8069-4-28.
PMCID: PMC2503974
Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury
Weijiao Xie, Misaki Matsumoto, Jerold Chun, and Hiroshi Ueda
Mol Pain. 2008; 4: 46. Published online 2008 October 15. doi: 10.1186/1744-8069-4-46.
PMCID: PMC2599895
Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia
Michiko Nishiyori and Hiroshi Ueda
Mol Pain. 2008; 4: 52. Published online 2008 November 6. doi: 10.1186/1744-8069-4-52.
PMCID: PMC2596100
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