From clinical trials to community: The science of translating diabetes and obesity research
Natcher Conference Center,
Bethesda Md
January 12-13, 2004
Summary
Dramatic advances in diabetes treatment and prevention have occurred over the past decade. Landmark clinical trials such as the Diabetes Control and Complications Trial (DCCT) and the United Kingdom Prospective Diabetes Study (UKPDS) have demonstrated the importance of intensive blood glucose and blood pressure control. More recently, the Diabetes Prevention Program (DPP) showed that lifestyle intervention, addressing weight loss and maintenance and increased exercise, as well as treatment with the drug metformin, delay or prevent the onset of type 2 diabetes in people at high risk for developing the disease.
Unfortunately, the therapies proven to delay or prevent either the complications of type 1 or type 2 diabetes or the onset of type 2 diabetes have not been widely incorporated. In addition, information that will require implementation is likely to become available in the near future from ongoing clinical trials that address prevention/treatment of type 1 or type 2 diabetes and/or obesity.
Translational research aims to determine what can improve outcomes in diverse, real-world populations and how to achieve these goals in a practical way that positively affects public health. This conference is organized by the NIDDK in collaboration with the NIH Office of Behavioral and Social Sciences Research and the CDC. It will bring together investigators, health care providers, NIH representatives, and payers to discuss barriers to translation, translational research, translational interventions, community-based approaches, and public health efforts. A primary conference objective is to foster ideas to improve treatment for individuals with or at risk for diabetes through implementation of known and newly emerging prevention and treatment strategies.
The afternoon of the second day of the conference will be devoted to a “Grant Writing Workshop” targeted to investigators interested in submitting translational research proposals. The faculty will include NIH experts on the grant writing process and individuals with successful grant writing and grant review expertise.
AGENDA
Day 1 Monday, January 12, 2004
7:30 am Continental Breakfast and Registration
8:30 am Opening Remarks
Welcome and Introduction – Sanford Garfield, Allen Spiegel (Director, NIDDK)
Morning Session Moderator – Roland Hiss
Fundamental Issues in Translational Research – Roland Hiss (Moderator)
9:00 am Translational Research – Two Phases in a Continuum – Roland Hiss
9:20 am Efficacy vs. Effectiveness Studies – Lawrence Green9:50 am Discussion
10:10 am BREAK
Outcomes for Translational Research – Russell Glasgow (Moderator)
10:35 am Introduction
10:45 am What Outcomes Are Most Important for Translational Research?– Russell Glasgow
11:15 am Quality of Life Outcomes in Translation Research – KM Venkat Narayan
11:40 am Methodological Issues in Economic Evaluation – David Meltzer
(Each of the above 3 sessions includes a 5-minute question-and-answer session)
12:05 pm Panel Discussion
12:35 pm LUNCH
Afternoon Session Moderator – Lawrence Green
Experimental Design Issues in Translational Research – Marshall Chin (Moderator)
1:30 pm Introduction
1:40 pm Linkages of Question to Design – Carol Mangione
2:05 pm Multi-Level Interventions – Joseph Selby
2:30 pm Community-Based Participatory Research – Marshall Chin(Each of the above 3 sessions includes a 5-minute question-and-answer session)
2:55 pm Panel Discussion
3:20 pm BREAK
Review and Critique of Translational Research Studies – Marshall Chin (Moderator)
3:45 pm Moving Translational Research Forward: Do We Need a GPS? – Barbara Rimer
4:15 pm Perspective of NIH Review Committees – Alan Delamater
4:50 pm Translational Research: The Journal Editors’ View – David Cooper, JAMA– Hal Sox, Annals of Internal Medicine
5:20 pm ADJOURN
Day 2 Tuesday, January 13, 2004
7:30 am Continental Breakfast/Meet the Professor Sessions
The Outlook for Translational ResearchMorning Session Moderator – Sanford Garfield
8:30 am Translating the DPP – David Marrero
9:00 am Translational Issues in Obesity – Ken Resnicow
9:30 am BREAK
10:00 am Effectiveness Studies in Support of the Chronic Disease Model – David Stevens
10:30 am Translational Research at the CDC – Frank Vinicor
11:00 am The Future of Translational Research at the NIDDK – Allen Spiegel
11:20 am The Future of Translational Research at the NIH – Raynard Kington
11:45 am CONFERENCE ADJOURNS
Afternoon Session – Grant Writing Workshop
Page last updated: November 25, 2008
