Table of Contents



The National Cancer Institute (NCI)
An Institution Dedicated to Discovery




Progress Against Cancer

The Growth in Knowledge
Reducing the Burden--The NCI's Ultimate Goal



The NCI's Research Programs

Research Settings
Research Areas
Cancer Biology
Cancer Risk
Cancer Interventions
Cancer Control



Key Changes in Organization
Reorganization to Maximize Progress and Prioritize Expenditures




The National Investment in Cancer Research

The NCI Budget Estimate




The NCI's Infrastructure for Discovery
Mechanisms and Requested Funding

Research Project Grants
The Single Research Project Grant and its Derivatives
The Program Project Mechanism
Intramural Research
Cancer Centers
Clinical Trials
Cooperative Group Clinical Trials Program
Community Clinical Oncology Program
Training and Education
Research Support Contracts
Cancer Control
Spreading the Word: The NCI's Information Dissemination Mandate
AIDS Research
Research Management and Support
Other Research Support




Budget for the NCI's Infrastructure for Discovery



Extraordinary Opportunities for New Investments

The Criteria for an Extraordinary Opportunity for Investment
Cancer Genetics
Preclinical Models of Cancer
Detection Technologies
Developmental Diagnostics
Investigator-Initiated Research: A Discovery Engine




Budget for the NCI's Infrastructure for Discovery Plus
New Opportunities for Investment




Summary



Vignettes

BRCA1: A Breast and Ovarian Cancer Gene
Rehabilitation and Pain Control
Children and Smoking
Prostate Cancer
Testicular Cancer
Conservative Breast Cancer Therapy
Hereditary Non-Polyposis Colorectal Cancer (HNPCC)