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2001 Progress Report: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures

EPA Grant Number: R827353C010
Subproject: this is subproject number 010 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
Investigators: Speizer, Frank E.
Current Investigators: Speizer, Frank E. , Park, S.
Institution: Harvard University
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2000 through May 31, 2001
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter

Description:

Objective:

This project is one of three under Theme III: Biological Mechanisms and Dosimetry. The objective of this research project is to investigate associations of selected inflammatory and blood-clotting parameters in free-living humans with particle and criteria gas exposures.

Progress Summary:

This Center works in collaboration with the Boston Veterans Hospital on this project. During the first 3 years of this project, the Boston Veterans Hospital has been collecting data. Measurements of approximately 650 individuals out of 1,200 participants have been completed. Statistical analysis, relationships to ambient pollution levels and geographical relationships, has just commenced.

A new panel study commenced this past spring in St. Louis, MO. Forty-four elderly individuals from four senior independent living facilities were enrolled for participation in the study. To evaluate the effect of traffic-related air pollution on cardiovascular health, individuals participated in a series of four separate day-trips from their suburban residences to activities in downtown St. Louis. Each day trip included two 1-hour bus rides on a shuttle bus.

To characterize gaseous and particulate exposures before, during, and after the bus trips, a number of continuous samplers were employed. These samplers were installed on two roll-around carts and in the rear of the shuttle bus. Continuous measurements of cardiac function also were collected during each day of participation using Holter monitors. In addition, samples of exhaled nitric oxide, blood pressure, blood oxygen, and blood samples were collected from participants before and after the trips.

This field study was completed in July 2002. Data processing and statistical analysis are now underway to investigate the relationship between cardiovascular function and human exposures to traffic-related air pollution.

Future Activities:

In the coming year, we will be involved in analysis of data from both the Boston Veterans Hospital and the St. Louis studies.

Journal Articles:

No journal articles submitted with this report: View all 6 publications for this subproject

Supplemental Keywords:

inflammatory, blood, blood clotting parameters, blood viscosity, heart rate, heart rate variability, particulate matter, PM, criteria gas. , Air, Geographic Area, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Biology, Risk Assessments, Disease & Cumulative Effects, Epidemiology, air toxics, Atmospheric Sciences, Environmental Engineering, particulate matter, Environmental Chemistry, Environmental Monitoring, State, ambient measurement methods, cardiopulmonary, risk assessment, exposure and effects, gaseous co-polutants, heart rate, traffic related air pollution, ambient air quality, cardiovascular disease, chronic effects, elderly, health effects, indoor air quality, inhalation, cardiac arrhythmia, developmental effects, epidemelogy, lung cancer, respiratory disease, inhalation toxicology, air quality, ambient air, cardiopulmonary response, molecular epidemiology, cardiac ischemia, cardiopulmonary responses, human health risk, interindividual variability, monitoring, genetic susceptibility, particle exposure, toxics, air pollutants, human health effects, particulates, respiratory, sensitive populations, ambient particle health effects, blood viscosity, air pollution, children, inhaled, metals, ambient air monitoring, chemical exposure, automotive emissions, atmospheric particulate matter, dosimetry, exposure, inhaled particles, pulmonary, human health, cardiopulmonery responses, human susceptibility, particle chemical composition, biological mechanism , health risks, human exposure, Human Health Risk Assessment, particle size, PM, pulmonary disease, Massachusetts (MA)
Relevant Websites:

http://www.hsph.harvard.edu/epacenter exit EPA

Progress and Final Reports:
2000 Progress Report
Original Abstract
2002 Progress Report
2003 Progress Report
Final Report


Main Center Abstract and Reports:
R827353    EPA Harvard Center for Ambient Particle Health Effects

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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