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2006 Progress Report: Harvard Particle Center
EPA Grant Number: R832416Center: Harvard Particle Center
Center Director: Koutrakis, Petros
Title: Harvard Particle Center
Investigators: Koutrakis, Petros , Godleski, John J. , Gold, Diane R. , Schwartz, Joel , Silverman, Frances , Sparrow, David , Suh, Helen H. , Vokonas, Pantel
Institution: Boston University , Harvard University , University of Toronto
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: October 1, 2005 through September 30, 2010
Project Period Covered by this Report: October 1, 2005 through September 30, 2006
Project Amount: $3,215,324
RFA: Particulate Matter Research Centers (2004)
Research Category: Particulate Matter
Description:
Objective:The fundamental objective of the Center is to understand how specific particulate matter (PM) characteristics and sources impact inflammation, autonomic responses, and vascular dysfunction.
Progress Summary:Overview
The EPA Particle Center at the Harvard School of Public Health (HSPH) originally planned to include five projects: Project 1, with a focus on exploring the pathways of particle toxicity for cardiovascular responses in the Normative Aging Study; Project 2, with a focus on the cardiovascular effects of particles and gaseous co-pollutants from mobile sources; Project 3, with a focus on cardiovascular toxicity of concentrated ambient fine, ultrafine and coarse particles, using controlled human exposures; Project 4, with a focus on assessing toxicity of local and transported ambient particles using animal models exposed to CAPs; and Project 5, with a focus on assessing toxicity of vehicular emissions, using animal models.
However, after careful consideration of the questions and concerns raised by our Science Advisory Committee during our July 2006 meeting, we decided to eliminate Project 2 and redirect funds to extend Project 1 by continuing health and pollution measurements for our NAS cohort for the duration of the Center. Project 3 (RD832416C002) will be conducted during Years One through Five, Project 4 (RD832416C003) during Years One through Three, and Project 5 (RD832416C004) during Years Three through Five. The first year progress reports for the Center include preliminary results for Projects 1, 3, and 4.
Journal Articles: 18 Displayed | Download in RIS Format
| Other center views: | All 18 publications | 18 publications in selected types | All 18 journal articles |
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Alexeeff SE, Litonjua AA, Suh H, Sparrow D, Vokonas PS, Schwartz J. Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA Normative Aging Study. Chest 2007;132(6):1890-1897. |
R832416 (2006) R827353 (Final) |
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Alexeeff SE, Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. Statin use reduces decline in lung function: VA Normative Aging Study. American Journal of Respiratory and Critical Care Medicine 2007;176(8):742-747. |
R832416 (2006) R827353 (Final) |
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Baccarelli A, Martinelli I, Zanobetti A, Grillo P, Hou LF, Bertazzi PA, Mannucci PM, Schwartz J. Exposure to particulate air pollution and risk of deep vein thrombosis. Archives of Internal Medicine 2008;168(9):920-927. |
R832416 (2006) R827353 (Final) |
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Baccarelli A, Cassano PA, Litonjua A, Park SK, Suh H, Sparrow D, Vokonas P, Schwartz J. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation 2008;117(14):1802-1809. |
R832416 (2006) R827353 (Final) |
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Chahine T, Baccarelli A, Litonjua AA, Wright RO, Suh H, Gold DR, Sparrow D, Vokonas PS, Schwartz J. Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environmental Health Perspectives 2007;115(11):1617-1622. |
R832416 (2006) R827353 (Final) |
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Chen JC, Schwartz J. Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environmental Health Perspectives 2008;116(5):612-617. |
R832416 (2006) R827353 (Final) |
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Franco Suglia S, Gryparis A, Wright RO, Schwartz J, Wright RJ. Association of black carbon with cognition among children in a prospective birth cohort study. American Journal of Epidemiology 2008;167(3):280-286. |
R832416 (2006) R827353 (Final) |
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Franklin M, Schwartz J. The impact of secondary particles on the association between ambient ozone and mortality. Environmental Health Perspectives 2008;116(4):453-458. |
R832416 (2006) |
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Franklin M, Koutrakis P, Schwartz J. The role of particle composition on the association between PM2.5 and mortality. Epidemiology 2008;19(5):680-689. |
R832416 (2006) |
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Liu Y, Koutrakis P, Kahn R. Estimating fine particulate matter component concentrations and size distributions using satellite-retrieved fractional aerosol optical depth:Part 1-method development. Journal of the Air & Waste Management Association 2007;57(11):1351-1359. |
R832416 (2006) R827353 (Final) |
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Liu Y, Koutrakis P, Kahn R, Turquety S, Yantosca RM. Estimating fine particulate matter component concentrations and size distributions using satellite-retrieved fractional aerosol optical depth: Part 2--a case study. Journal of the Air & Waste Management Association 2007;57(11):1360-1369. |
R832416 (2006) R827353 (Final) |
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Medina-Ramon M, Goldberg R, Melly S, Mittleman MA, Schwartz J. Residential exposure to traffic-related air pollution and survival after heart failure. Environmental Health Perspectives 2008;116(4):481-485. |
R832416 (2006) |
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Park SK, O’Neill MS, Vokonas PS, Sparrow D, Wright RO, Coull B, Nie H, Hu H, Schwartz J. Air pollution and heart rate variability: effect modification by chronic lead exposure. Epidemiology 2008;19(1):111-120. |
R832416 (2006) R827353 (Final) |
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Park SK, O’Neill MS, Vokonas PS, Sparrow D, Spiro A III, Tucker KL, Suh H, Hu H, Schwartz J. Traffic-related particles are associated with elevated homocysteine: the VA Normative Aging Study. American Journal of Respiratory and Critical Care Medicine 2008;178(3):283-289. |
R832416 (2006) R827353 (Final) |
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Schwartz J, Coull B, Laden F, Ryan L. The effect of dose and timing of dose on the association between airborne particles and survival. Environmental Health Perspectives 2008;116(1):64-69. |
R832416 (2006) |
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Wellenius GA, Yeh GY, Coull BA, Suh HH, Phillips RS, Mittleman MA. Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures study. Environmental Health 2007;6:26. |
R832416 (2006) R827353 (Final) |
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Zanobetti A, Schwartz J. Temperature and mortality in nine US cities. Epidemiology 2008;19(4):563-570. |
R832416 (2006) |
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Zanobetti A, Schwartz J. Is there adaptation in the ozone mortality relationship: a multi-city case-crossover analysis. Environmental Health 2008;7:22. |
R832416 (2006) |
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Air, Scientific Discipline, Health, RFA, Risk Assessments, Health Risk Assessment, particulate matter, Environmental Chemistry, ambient air quality, cardiovascular vulnerability, chemical characteristics, autonomic dysfunction, traffic related particulate matter, chemical composition, human health risk, oxidative stress, human health effects, toxicology, automobile exhaust, ambient particle health effects, atmospheric particulate matter, biological mechanism , airborne particulate matter, human exposure
Relevant Websites:
http://www.hsph.harvard.edu/epacenter/
Progress and Final Reports:
Original Abstract
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832416C001 Cardiovascular Responses in the Normative Aging Study: Exploring the Pathways of Particle Toxicity
R832416C002 Cardiovascular Toxicity of Concentrated Ambient Fine, Ultrafine and Coarse Particles in Controlled Human Exposures
R832416C003 Assessing Toxicity of Local and Transported Particles Using Animal Models Exposed to CAPs
R832416C004 Cardiovascular Effects of Mobile Source Exposures: Effects of Particles and Gaseous Co-pollutants
R832416C005 Toxicological Evaluation of Realistic Emission Source Aerosol (TERESA): Investigation of Vehicular Emissions