![[logo] US EPA](https://webarchive.library.unt.edu/eot2008/20081111032836im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
EPA Grant Number: R827355C005Subproject: this is subproject number 005 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
Investigators: Luchtel, Daniel L. , Ladiges, Warren , Larson, Timothy V. , Lewtas, Joellen
Current Investigators: Luchtel, Daniel L. , Baker, Coralie , Ceballos, Diana , Kavanagh, Terry , Leaman, Susan , McConnachie, Lisa , Rosenfeld, Michael
Institution: University of Washington
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 30, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:The toxicology project uses transgenic mouse strains, initially those selected for cardiovascular disease, as animal model(s) for exploring the mechanisms of PM-related acute morbidity and mortality. This model will be used to test the hypotheses that in compromised individuals (age, disease status), inhaled PM initiate production by cells in the lung of inflammatory mediators and oxidants, that then become blood-borne and target the cardiovascular system, leading to acute morbidity and mortality. Apart from use in validating and mechanistic studies, a susceptible mouse model will be useful in assessing relative potency of different ambient PM mixtures, leading to new hypotheses regarding causative agents. We hypothesize that inhaled PM causes release of inflammatory mediators from cells in the lung that become blood-borne and target the cardiovascular system, particularly the heart. In compromised individuals (age, diet, disease status), the cascade of mediators released from the lung acts on the cardiovascular system and causes acute morbidity and mortality. We will use transgenic mouse strains with specific cardiovascular genetic alterations to address the research need to identify potential health conditions that enhance susceptibility to adverse PM health effects. The nature of such health conditions should then provide insight into the biological mechanisms by which PM mediates acute and chronic health effects. Publications and Presentations:
Publications have been submitted on this subproject: View all 8 publications for this subproject | View all 191 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 1 journal articles for this subproject | View all 94 journal articles for this center
Supplemental Keywords:particulate matter, PM, human health effects, asthma, COPD, heart disease, Seattle, Spokane, Washington, WA, exposure, air pollution. , Air, Scientific Discipline, Health, Toxicology, Risk Assessments, Health Risk Assessment, Epidemiology, air toxics, Atmospheric Sciences, Biochemistry, particulate matter, Environmental Chemistry, aerosols, exposure assessment, exposure and effects, ambient air quality, cardiovascular disease, health effects, inhalation, mortality, hazardous air pollutants, atmospheric aerosols, cardiopulmonary responses, human health risk, particle exposure, mortality studies, air pollutants, human health effects, particulates, ambient particle health effects, air pollution, atmospheric chemistry, exposure, ambient aerosol, human exposure, morbidity, animal model
Progress and Final Reports:
1999 Progress Report
2000 Progress Report
2001 Progress Report
2002 Progress Report
2003 Progress Report
2004 Progress Report
Final Report
Main Center Abstract and Reports:
R827355 Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary
Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers