Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
EPA Grant Number: R827351C008Subproject: this is subproject number 008 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: Lippmann, Morton
Title: Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
Investigators: Cohen, Mitchell
Institution: NYU School of Medicine
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:The objective of this research project is to reveal which of the many metals present in PM (alone or in combination) might be responsible for any effects on leukocyte function, or the mechanism(s) of action underlying these effects. Epidemiological studies show that PM induces/exacerbates infectious lung disease (e.g., pneumonia), and toxicological studies show that PM can alter the manner by which the lungs handle bacterial infections. Metals, a major component of PM, are a class of toxicants known to be immunomodulatory. Several metals produce effects upon directly-exposed immune cells (i.e., pulmonary macrophages (PAM) and pulmonary neutrophils (PMN)) that decreases their antibacterial activities in the lungs.
Publications and Presentations:Publications have been submitted on this subproject: View all 5 publications for this subproject | View all 95 publications for this center
Journal Articles:Journal Articles have been submitted on this subproject: View all 5 journal articles for this subproject | View all 74 journal articles for this center
Supplemental Keywords:particulate matter, PM, exposure, epidemiology, toxicology, metals, pulmonary macrophage, pulmonary neutrophil, leukocyte, Los Angeles, California, CA, Seattle, Washington, WA.
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ENVIRONMENTAL MANAGEMENT, Air, Scientific Discipline, Health, RFA, PHYSICAL ASPECTS, Risk Assessment, Risk Assessments, Analytical Chemistry, Health Risk Assessment, Physical Processes, Atmospheric Sciences, particulate matter, Environmental Chemistry, Environmental Monitoring, exposure assessment, pulmonary phagocyte iron status, ambient air quality, chemical characteristics, epidemelogy, metal absorption, human health risk, lung injury, pneumonia, air toxics, particulates, Sulfur dioxide, toxicology, atmospheric particles, acute lung injury, air pollution, environmental risks, metals, ambient air monitoring, atmospheric particulate matter, leukocyte function, exposure, atmospheric aerosol particles, airborne particulate matter, human exposure, PM
Progress and Final Reports:
2000 Progress Report
2001 Progress Report
2002 Progress Report
2003 Progress Report
Final Report
Main Center Abstract and Reports:
R827351 EPA NYU PM Center: Health Risks of PM Components
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827351C001 Exposure Characterization Error
R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
R827351C003 Asthma Susceptibility to PM2.5
R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
R827351C009 Health Risks of Particulate Matter Components: Center Service Core
R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
R827351C011 Urban PM2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
R827351C013 Long Term Health Effects of Concentrated Ambient PM2.5
R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
R827351C016 Automated Real-Time Ambient Fine PM Monitoring System