Selenium and Compounds Quickview (CASRN 7782-49-2)

Status of Data for Selenium and Compounds

File First On-Line: 03/01/1991; Last Significant Revision: 06/01/1991

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	09/01/1991
Inhalation RfC Assessment	No data
Carcinogenicity Assessment	On-line	07/01/1993

Synonyms

7782-49-2 Selenium Caswell No. 732 Elemental Selenium HSDB 4493

Selen [polish] Selenio [Spanish] Selenium Selenium alloy more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Clinical selenosis	NOAEL : 0.015 mg/kg-day	3	1	5 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • Human epidemiological study, Yang et al., 1989b
• Confidence in the Oral RfD
  • Study -- Medium
  • Database -- High
  • RfD -- High

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • D (Not classifiable as to human carcinogenicity)
• Weight-of-Evidence Narrative:
  • Based on inadequate human data and inadequate evidence of carcinogenicity in animals. The evidence for various selenium compounds in animal and mutagenicity studies is conflicting and difficult to interpret; however, evidence for selenium sulfide is sufficient for a B2 (probable human carcinogen) classification.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

• Not Assessed under the IRIS Program.

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.