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Allyl chloride Quickview (CASRN 107-05-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Allyl chloride

File First On-Line: 09/01/1990; Last Significant Revision: 12/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment On-line 05/01/1995
Carcinogenicity Assessment On-line 08/01/1994
Synonyms
  • 107-05-1
  • Allile (cloruro di) [Italian]
  • Allylchlorid [German]
  • Allyl chloride
  • Allyle (chlorure d') [French]
  • p-aminopropiofenon [Czech]
  • Chlorallylene
  • 3-Chloroprene
  • 1-Chloro-2-propene
  • more...
Allyl chloride Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
 UF MF RfC
Functional and histological peripheral neurotoxicity NOAEL (HEC): 3.6 mg/m3 3000 1 1x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Classification is based on a low (but biologically important) incidence of forestomach tumors in female mice and positive results in a variety of genetic toxicity tests. Allyl chloride is an alkylating agent and structurally related to probable human carcinogens.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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